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The COVID-19 pandemic highlights the importance of good nutritional status for immune strength and for reducing comorbidities that increase morbidity and mortality of infections. The major aim of this study is test if almond consumption can improve immune function.
Investigators will conduct an 8-week parallel-arm trial of 48 overweight/non-obese (BMI=24-30) adult (aged 40-65 years) men (n=24) and women (n=24) who will be randomly assigned to consume daily isoenergetic portions of almonds or a common snack (pretzels).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Almond (2 ounces) | Experimental | Consume 2 ounces almond daily for 8 weeks |
|
| Pretzel | Active Comparator | Consume comparative amount of pretzel for 8 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Almond | Other | Consume 2 ounces of almond daily for 8 weeks |
| |
| Measure | Description | Time Frame |
|---|---|---|
| change in Natural Killer Function | The ability of peripheral blood mononuclear cells to bind and kill leukemia cells will be measured at baseline and at week-8 of the diet intervention using flowcytometry by assessing the concentration of natural killer cells. | Baseline, after 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| change in Cytokines | Peripheral blood will be analyzed at baseline and week-8 of diet intervention for cytokines including IL1, IL-6 and TNF alpha concentrations. | Baseline, after 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Shirin Hooshmand, PhD, RD | San Diego State University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mark Kern, PhD, RD | San Diego | California | 92182-7251 | United States |
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forty-eight overweight/non-obese (BMI=24-30) adult (ages 40-65 years) men (n=24) and women (n=24) will be recruited to participate. A randomized, parallel-arm design will be utilized.
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| Pretzel |
| Other |
Consume comparative amount of pretzel daily for 8 weeks |
|