Labor Induction in Preeclampsia High-risk Women

Labor Induction Versus Expectant Management in High-risk Women for Preeclampsia

Preeclampsia (PE) is one of the leading causes of maternal and perinatal morbidity and mortality. This pregnancy-specific disorder poses to both pregnant women and their offspring an increased risk of immediate and long-term health problems. The study team is conducting a study entitled "FORECAST" (Implementation of First-trimester Screening and preventiOn of pREeClAmpSia Trial) and established the infrastructure for the first-trimester "screen and prevent" program for preterm PE. However, there is no established evidence regarding the benefit of scheduled labor induction versus expectant management among women identified as high-risk for PE with uncomplicated pregnancy at term. The investigators postulate that induction of labor at 39 weeks' gestation may possibly be an effective intervention to reduce placental complications in women with uncomplicated pregnancy by 39 weeks at high-risk PE women.

Inclusion Criteria:

• Age no less than 18 years
• Singleton pregnancy with cephalic presentation and no contraindication to vaginal delivery
• Live fetus
• Screened high-risk for PE
• Informed and written consent

Exclusion Criteria:

• Multiple pregnancy
• Pregnant women who plan to have Cesarean delivery
• Pregnancies complicated by the major fetal abnormality
• Women who are severely ill, those with learning difficulties, or serious mental illness
• Pregnant women with medical, obstetric, or fetal complications or any other indications for delivery before 39 weeks' gestation