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Acute type A aortic dissection is often accompanied by postoperative hypoxemia, the cause of which is not fully understood. Angiotensin II is an important component of the renin-angiotensin system (RAS), which has been suggested to be involved in the development of aortic dissection and pulmonary inflammation.The purpose of this study was to investigate the role and mechanism of angiotensin II pathway in postoperative hypoxemia after acute type A aortic dissection, and to provide reference for clinical application
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hypoxemia group | oxygenation index (OI)≤200 |
| |
| Non-hypoxemia group | oxygenation index (OI)>200 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | No intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| The Difference Concentrations of ANG II in Serum Between Patients With and Without Postoperative Hypoxemia. | Blood samples were taken within 24 hours after operation to detect the contents of ANG II in serum. Postoperative hypoxemia is defined by the oxygenation index (OI), which is the ratio of arterial partial pressure of oxygen to fraction inspired oxygen (PaO2 / FiO2), of less than or equal to 200 for two consecutive times within the first 24 h after operation | Within 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| The Risk Factors for Postoperative Hypoxemia in Stanford Type A Acute Aortic Dissection Patients. | Basic characteristics, intraoperative details, biochemical parameters and outcome results were obtained, and blood was collected within 24 hours after surgery for the measurement of ANG II, sACE2 and mir-145 concentrations. Univariate analysis was first performed to identify the potential risk factors for postoperative hypoxemia. Multivariate logistic regression analysis was performed for factors with P < 0.05 or that were considered clinically important. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing surgical treatment for acute type A aortic dissection in our hospital were selected. The age was 18 years ≤ age ≤80years, and gender was not limited. The overall study patients were divided into the hypoxemia group and non-hypoxemia group according to the presence or lack of hypoxemia after surgery.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Anzhen hospital, Beijing | Beijing | Beijing Municipality | 100029 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37603505 | Derived | Wang X, Ma J, Lin D, Dong X, Wu J, Bai Y, Zhang D, Gao J. The risk factors of postoperative hypoxemia in patients with Stanford type A acute aortic dissection. Medicine (Baltimore). 2023 Aug 18;102(33):e34704. doi: 10.1097/MD.0000000000034704. |
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| ID | Title | Description |
|---|---|---|
| FG000 | Hypoxemia Group | oxygenation index (OI)≤200 No intervention: No intervention |
| FG001 | Non-hypoxemia Group | oxygenation index (OI)>200 No intervention: No intervention |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Hypoxemia Group | oxygenation index (OI)≤200 No intervention: No intervention |
| BG001 | Non-hypoxemia Group | oxygenation index (OI)>200 No intervention: No intervention |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | The Difference Concentrations of ANG II in Serum Between Patients With and Without Postoperative Hypoxemia. | Blood samples were taken within 24 hours after operation to detect the contents of ANG II in serum. Postoperative hypoxemia is defined by the oxygenation index (OI), which is the ratio of arterial partial pressure of oxygen to fraction inspired oxygen (PaO2 / FiO2), of less than or equal to 200 for two consecutive times within the first 24 h after operation | Posted | Median | Inter-Quartile Range | pg / mL | Within 24 hours after surgery |
|
One month after surgery
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Hypoxemia Group | oxygenation index （PaO2 / FiO2）≤200 | 1 |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Jun Ma | Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University | 13370103671 | majun@mail.ccmu.edu.cn |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Mar 1, 2022 | Apr 13, 2023 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D000784 | Aortic Dissection |
| ID | Term |
|---|---|
| D000094665 | Dissection, Blood Vessel |
| D000783 | Aneurysm |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| up to 60 days |
| Duration of Stay in the Intensive Care Unit | Duration of Stay in the intensive care unit after surgery | up to 60 days |
| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Race (NIH/OMB) | Count of Participants | Participants |
|
| Weight | Mean | Standard Deviation | Kg |
|
| Hight | Mean | Standard Deviation | cm |
|
| BMI | Mean | Standard Deviation | kg / m2 |
|
|
|
| Secondary | The Risk Factors for Postoperative Hypoxemia in Stanford Type A Acute Aortic Dissection Patients. | Basic characteristics, intraoperative details, biochemical parameters and outcome results were obtained, and blood was collected within 24 hours after surgery for the measurement of ANG II, sACE2 and mir-145 concentrations. Univariate analysis was first performed to identify the potential risk factors for postoperative hypoxemia. Multivariate logistic regression analysis was performed for factors with P < 0.05 or that were considered clinically important. | Not Posted | up to 60 days | Participants |
| Secondary | Duration of Stay in the Intensive Care Unit | Duration of Stay in the intensive care unit after surgery | Not Posted | up to 60 days | Participants |
| 25 |
| 0 |
| 25 |
| 0 |
| 25 |
| EG001 | Non-hypoxemia Group | oxygenation index （PaO2 / FiO2）>200 | 0 | 63 | 0 | 63 | 0 | 63 |
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| D000094683 |
| Acute Aortic Syndrome |
| D001018 | Aortic Diseases |