This randomized, open label, dose-response study will be realized at the first line with Bactecal® D Liquid. The objective is to investigate Bactecal® D Liquid in the context of infantile colics.

The patients will be randomized into two arms, A and B, in function of the intervention dose. The quality of life of te parents as well as the daily median crying time and the number of daily crying will be assessed.

Inclusion Criteria:

• Full term healthy infant (37-41 weeks amenorrhea)
• Birth weight >2750 g
• Aged between 2 and 8 weeks
• Presenting symptoms of infant colic as defined by Rome IV criteria by Zeevenhoven et al. 2017
• Signed written informed consent of the parent/tutor

Exclusion Criteria:

• Premature birth
• Using probiotics as a treatment, different from the one that could contain the formula at the time of study recruitment
• Acute or chronic illness as judged by the investigator which avoids the participation to the study .
• Parents unable to understand the requirements of study participation as judged by the investigator
• Malnutrition as judged by a body weight/height ratio <5 %