This Clinical trial study for the effect of a product E-PR-01 will be studied for its ability to attain rapid pain relief in the individuals suffering from exercise-induced knee joint pain, as well as determine its sustained effect on pain reduction over a treatment period of five days.

The study is a randomized, double-blind, placebo controlled, cross-over study to explore the effect of a product E-PR-01 on joint pain. Approximately 50 participants aged between ≥ 20 and ≤ 60 years will be screened. At least 40 participants will be randomized, and the participants will be crossed over both the IP and placebo arms. A minimum of 32 participants must complete the study, after accounting for the screening failure and dropout /withdrawal rate of 20% each. The duration of each treatment for all the study participants will be 5 days, the washout period between each treatment period being 5 ± 2 days.

The total study period from the first start of treatment visit, inclusive of the washout and treatment periods, is estimated to be 15 days.

Inclusion Criteria:

1. Physically active adults aged ≥20 and ≤60 years with history of knee joint pain aggravation on physical stress (walking, running, cycling etc.).
2. Body Mass Index (BMI) ≥ 20 and ≤ 29.9 kg/m2.
3. Participants with self-reported joint pain of ≥ 60 on 100 mm VAS scale after walking on treadmill using modified Naughton's protocol.
4. Participants with no or minimal pain at rest (≤ 30 mm on VAS scale).
5. Participants willing to complete all the study procedures including study-related questionnaires and tasks, and comply with the study requirements.
6. Participants willing to abstain from the restricted supplements and medications prior to inclusion and throughout the study period.
7. Participants with the ability to read and provide written, personally signed, and dated informed consent to participate in the study.

Exclusion Criteria:

1. Known cases of osteo-, rheumatic- or any other form of arthritis.

2. Participants fulfilling ≥ 3 of the following ACR criteria:

   i. Over the age of 50 years ii. Less than 30 minutes of morning stiffness iii. Crepitus on active motion iv. Bony tenderness v. Bony enlargement vi. No palpable warmth at the knee

3. Participants suffering from Insomnia and restless leg syndrome.

4. Participants with uncontrolled Hypertension, as characterized by Systolic Blood Pressure (SBP) >139 mmHg and Diastolic Blood Pressure >89 mmHg.

5. Participants currently on anti-hypertensives

6. Participants suffering from Type II Diabetes Mellitus.

7. Participants with history of lower limb injure in the past six months.

8. Participants currently on joint health supplements and medications.

9. Participants with a history of knee surgery, replacement, or any non-knee surgical procedures that may impact the study outcomes

10. Participants who have used Intraarticular injections in the last six months.

11. Participants who have undergone a significant cardiovascular event in the past six months.

12. Individuals with history of hyperacidity with at least one episode/ week.

13. Individuals with diagnosed cases of migraine.

14. History or presence of clinically significant renal, hepatic, endocrine, biliary, gastrointestinal, pancreatic, or neurological disorders, that in the judgment of the investigator, would interfere with the participant's ability to provide informed consent, comply with the study protocol (which might confound the interpretation of the study results), or put the participant at undue risk.

15. Participants who have any other disease or condition, or are using any medication, that in the judgment of the investigator would put the participant at unacceptable risk for participation in the study or may interfere with evaluations in the study or noncompliance with treatment or visits.

16. Females who are pregnant/planning to be pregnant/lactating or taking any oral contraceptives.

17. Participants who have participated in a study of an investigational product 90 days prior to the screening.

18. Participants with heavy alcohol consumption, defined as For men: More than 14 standard alcoholic drink (SAD)/week or more than 4 SAD in a day.

    For women: More than 7 SAD/week or more than 3 SAD in a day.

19. Binge drinkers, defined as 4 or more SAD for women, and 5 or more SAD for men, in a 2-hour time frame.