The aim of this project to characterize systemic and organ-specific (subcutaneous adipose tissue and skeletal muscle) metabolic responses at rest and during standardized, moderate exercise after an oral glucose load in patients with various geneticaly heritable foms of skeletal muscle dystrophies. Metabolic responses will be monitored by indirect calorimetry (canopy and/or metabolic chamber at rest and during exercise) and microdialysis (adipose tissue and skeletal muscle at rest) before and after an oral glucose load (75 g).

Inclusion Criteria:

• controls: healthy, no metabolic, endocrine, neurologic or other diseases
• patients: genetically confirmed diagnosis of muscle dystrophy

Exclusion Criteria:

• known hemorrhagic diseases / coagulopathies
• intake of oral anti-coagulant drugs (control of PTT, INR and platelet count before study entry)
• insulin-dependent Diabetes mellitus
• pregnancy and lactation period
• chronic use of non-steroidal antiphlogistics
• alcohol and drug abuse
• Claustrophobia • gleichzeitige Teilnahme an einer anderen Studie; Teilnahme an einer Studie vor weniger als zwei Monaten Unfähigkeit, die mündlichen und schriftlichen Informationen zur Studie zu verstehen und das schriftliche Einverständnis zu geben

• out-patient clinic at Charité Universitätsmedizin Berlin, Campus Buch
• University Campus of Charité Universitätsmedizin Berlin