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| Name | Class |
|---|---|
| First Affiliated Hospital of Fujian Medical University | OTHER |
| Maoming Hospital Affiliated to Southern Medical University | UNKNOWN |
| Shenzhen People's Hospital | OTHER |
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As a multi-center, retrospective observation study in southern China, this study included the main study population of patients who underwent coronary angiography at 5 hospitals from Guangzhou, Shenzhen, Yangjiang, Maoming and Longyan from January 2000 to Decemeber 2020. The hospitalization information was collected in the form of direct derivation of the case, and cardiac and renal adverse events were collected through outpatient system. Data on all-cause death were obtained from the Guangdong Provincial Public Security and matched to the electronic Clinical Management System of the Guangdong Provincial People's Hospital records.
This is a multi-center, retrospective observation study collecting data on 184855 coronary angiography patients from January 2000 to Decemeber 2020. Data regarding demographic information, admission diagnoses and history of present illness, biomarkers and details on preventive hydration and medications will be collected. The primary endpoint of this study is Adverse Cardiovascular and Kidney Events.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| coronary angiography | The investigators recruit all consecutive patients who were undergoing coronary angiography or percutaneous coronary intervention. |
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| Measure | Description | Time Frame |
|---|---|---|
| Contrast-Induced Acute Kidney Injury (CI-AKI 0.3) | defined as a ≥ 0.3 mg/dL absolute increase in serum creatinine from baseline during the first 48 hours after the procedure | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Cystatin C based CI-AKI (CI-AKI cyc) | Cystatin C based CI-AKI, defined as a ≥10% absolute increase in serum cystatin C during the first 24 hours after the procedure and and a ≥ 0.3 mg/dL absolute increase in serum creatinine from baseline during the first 48 hours after the procedure.mg/dL absolute increase in serum creatinine from baseline during the first 48 hours after the procedure. | 24-48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Contrast-induced Persistent kidney injury (CI-PKI) | Serum creatinine was measured by endpoint colorimetry or enzymatic assays. CI-PKI was defined as residual impairment of renal function indicated by a ≥ 25% reduction in creatinine clearance at 3 months in comparison with baseline. comparison with baseline. | 3 months |
Inclusion Criteria:
1. Patients referred to CAG or PCI;
Exclusion Criteria:
-
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The investigators reviewed all consecutive patients who were undergoing coronary angiography.
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| Name | Affiliation | Role |
|---|---|---|
| Yong Liu, MD,PhD | Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital | Study Director |
| Shiqun Chen, MS | Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangdong Provincial People's Hospital | Guangzhou | Guangdong | 510080 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41877106 | Derived | Pan W, Lu X, Zhou Z, Liu J, Zhang S, Huang H, He Y, Deng J, Ling Y, Ruan X, Jing L, Zhang W, Chen S, Liao X, Chen J, Zhuang X, Liu Y. Excess apolipoprotein B predicts long-term survival in statin-treated CAD irrespective of achieved LDL-C levels: a pooled cohort analysis. Lipids Health Dis. 2026 Mar 24;25(1):124. doi: 10.1186/s12944-026-02928-z. | |
| 41729387 |
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| ID | Term |
|---|---|
| D059347 | Cardio-Renal Syndrome |
| D003324 | Coronary Artery Disease |
| D007674 | Kidney Diseases |
| D024821 | Metabolic Syndrome |
| D051436 | Renal Insufficiency, Chronic |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| Yangjiang People's Hospital |
| OTHER |
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| The change of eGFR, calculate based on CrCl and serum cystatin C | The eGFR creatinine-cystatin C was calculated by the 2012 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) cystatin C equation: 135 *min(Scr/κ, 1)α * max(Scr/κ, 1)-0.601 * min(Scys/0.8, 1)-0.375 * max (Scys/0.8, 1)-0.711 * 0.995Age [* 0.969 if female] [* 1.08 if black], where Scr is serum creatinine, Scys is serum cystatin C, κ is 0.7 for females and 0.9 for males, α is -0.248 for females and -0.207 for males, min indicates the minimum of Scr/κ or 1, and max indicates the maximum of Scr/κ or 1. | 48-72 hours |
| Incidence of major adverse cardiovascular events |
all-cause mortality (cardiovascular and noncardiovascular) and cardiovascular events. |
| 3-12months |
| Follow-up major adverse cardiovascular and clinical events | We will follow up the patients by telephone and outpatient service to know the one year all-cause mortality (cardiovascular and noncardiovascular) and cardiovascular events. | 3-12months |
| All-cause mortality | Died for any reason | From the hospital admission, and up to 10 years |
| Liu J, Ruan H, Lu X, Ye W, Huang H, Tang S, Yuan Z, Huang Z, Chen S, Tan N, Chen J, Liu Y. Systemic inflammation affects the association between pericoronary fat attenuation index and adverse cardiovascular risk in patients with coronary artery disease. Int J Cardiovasc Imaging. 2026 Feb 23. doi: 10.1007/s10554-026-03662-4. Online ahead of print. |
| 41225370 | Derived | Lu X, Wei P, Tang S, Ye W, Huang Z, Yuan Z, Ruan H, Huang H, Zhang W, Wang C, Kang Y, Hu J, Li Z, Deng J, Li Y, Wu W, Ming WK, Wong CK, Tan N, Chen S, Liu J, Chen J, Liu Y. Pericoronary fat attenuation index on coronary CT angiography and cardiovascular risk in patients with coronary artery disease and chronic kidney disease. BMC Nephrol. 2025 Nov 12;26(1):632. doi: 10.1186/s12882-025-04549-7. |
| 39355575 | Derived | Deng L, Chen H, Xu Q, Han K, Liu J, Chen S, Deng J, Tian L, Li Z, Lu X, Liu Y, Liang Y. The High-Sensitivity C-Reactive Protein to High-Density Lipoprotein Cholesterol Ratio and the Risk of Contrast-Induced Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention. Rev Cardiovasc Med. 2024 Sep 23;25(9):338. doi: 10.31083/j.rcm2509338. eCollection 2024 Sep. |
| 39077077 | Derived | Zhou Z, Qiao L, Ling Y, He Y, Chang T, Lu H, Yu S, Liu J, Guo W, Chen S, Liu Y, Chen J. Intermediate Hyperglycemia Increases the Risk of All-Cause Mortality in Premature Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention. Rev Cardiovasc Med. 2023 Dec 13;24(12):352. doi: 10.31083/j.rcm2412352. eCollection 2023 Dec. |
| 39076427 | Derived | Xie Y, Xu X, Wang D, Zhou Y, Kang Y, Lai W, Lu H, Liu J, Chen S, Xu J, Yan X, Huang X, Liu Y. Fibrinogen-to-Albumin Ratio and Long-Term Mortality in Coronary Artery Disease Patients with Different Glucose Metabolism Status. Rev Cardiovasc Med. 2023 Nov 16;24(11):317. doi: 10.31083/j.rcm2411317. eCollection 2023 Nov. |
| 38737110 | Derived | Wu W, Jia C, Xu X, He Y, Xie Y, Zhou Y, Lu H, Liu J, Chen J, Liu Y. Impact of Platelet-to-HDL-Cholesterol Ratio on Long-Term Mortality in Coronary Artery Disease Patients with or Without Type 2 Diabetes: Insights from a Chinese Multicenter Cohort. J Inflamm Res. 2024 May 6;17:2731-2744. doi: 10.2147/JIR.S458950. eCollection 2024. |
| 38528580 | Derived | Jia C, Wu W, Lu H, Liu J, Chen S, Liang G, Zhou Y, Yu S, Qiao L, Chen J, Tan N, Liu Y, Chen J. Fibrinogen to HDL-Cholesterol ratio as a predictor of mortality risk in patients with acute myocardial infarction. Lipids Health Dis. 2024 Mar 25;23(1):86. doi: 10.1186/s12944-024-02071-7. |
| 38088947 | Derived | Lu J, He Y, Yang Y, Zhong X, Chen S, Wu B, Pan Y, Wang Y, Xiu J, Kang Y, Liu J, Liu Y, Chen S, Chen K, Chen L. Age-Related Effect of Uric Acid on Contrast-Induced Acute Kidney Injury of Patients Undergoing Coronary Angiography. Clin Interv Aging. 2023 Dec 7;18:2053-2061. doi: 10.2147/CIA.S419370. eCollection 2023. |
| 37754571 | Derived | Liu J, Chen S, Zhou Y, Huang H, Li Q, Liang Y, Dong S, Huang X, Chen L, Zheng X, Meng R, Jia C, Chen J, Tan N, Liu Y. Proportion and number of incident cancer deaths in coronary artery disease. Cancer Med. 2023 Oct;12(19):20140-20149. doi: 10.1002/cam4.6595. Epub 2023 Sep 27. |
| 37582730 | Derived | Liu J, Chen S, Zhou Y, Zheng X, Meng R, Tan N, Liu Y. Effect of cumulative radiation exposure from Coronary catheterization on lung cancer mortality. BMC Cancer. 2023 Aug 15;23(1):757. doi: 10.1186/s12885-023-11231-4. |
| 37103656 | Derived | Gao F, Huang Z, Liang J, Kang Y, Ling Y, He Y, Chen J, Hong D, Zhang Z, Xu S, Wang A, Yan X, Liu J, Liu Y, Chen S, Chen J. Association of malnutrition with all-cause and cardiovascular mortality in patients with mild to severe chronic kidney disease undergoing coronary angiography: a large multicenter longitudinal study. Int Urol Nephrol. 2023 Dec;55(12):3225-3236. doi: 10.1007/s11255-023-03566-5. Epub 2023 Apr 27. |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D006333 | Heart Failure |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |