Prevention With Oleanolic Acid of Insulin Resistance and Metabolic Syndrome in Adolescents
Prevention With Oleanolic Acid of Insulin Resistance and Metabolic Syndrome in Adolescents
Oleanolic acid (OA), a triterpene that is highly present in olive leaves, has been proposed as component of functional foods in the prevention of metabolic syndrome due to its anti-inflammatory activity. In this research project we will study the presence of OA in postprandial TRL in healthy adolescents and in normal weight. Moreover, THP-1 macrophages will be incubated with LPS for 48h after pretreatment with OA at different concentrations. Also, TRL will be isolated from healthy adolescents before and 2 and 5h postprandially after the intake of a meal containing the functional olive oil or common olive oil and incubated with THP-1 macrophages.
Inclusion Criteria:
-Participants without digestive, metabolic or oncologic disorders or any other pathology
Exclusion Criteria:
-Not having the informed consent signed by the parents