A PHASE 2/3, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PLACEBO CONTROLLED STUDY TO EVALUATE THE SAFETY AND EFFICACY OF 2 REGIMENS OF ORALLY ADMINISTERED PF 07321332/RITONAVIR IN PREVENTING SYMPTOMATIC SARS-COV-2 INFECTION IN ADULT HOUSEHOLD CONTACTS OF AN INDIVIDUAL WITH SYMPTOMATIC COVID-19
A PHASE 2/3, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PLACEBO CONTROLLED STUDY TO EVALUATE THE SAFETY AND EFFICACY OF 2 REGIMENS OF ORALLY ADMINISTERED PF 07321332/RITONAVIR IN PREVENTING SYMPTOMATIC SARS-COV-2 INFECTION IN ADULT HOUSEHOLD CONTACTS OF AN INDIVIDUAL WITH SYMPTOMATIC COVID-19
The purpose of this clinical trial is to learn whether the study medicine prevent symptoms of COVID-19 in adults who have been exposed to household member(s) with a confirmed symptomatic COVID-19 infection.
All participants in the study will receive treatment for COVID-19 as needed, based on their regular doctor's recommendation. Two-thirds of participants will also receive two study medicines (PF-07321332 and ritonavir) by mouth twice a day for either five or ten days. We will compare the experiences of people receiving the study medicines to those of the people who do not. This will help us determine if the study medicines are safe and effective
Inclusion Criteria:
Exclusion Criteria:
Rosario, Santa Fe Province 2000, Argentina
Haskovo, 6300, Bulgaria
Sliven, 8800, Bulgaria
Stara Zagora, 6000, Bulgaria
Vratsa, 3000, Bulgaria
Bogota, Cundinamarca 110221, Colombia
Toshimaku, Tokyo 171-0014, Japan
Tijuana, Estado de Baja California 22010, Mexico
Monterrey, Nuevo León 64060, Mexico
Saint Petersburg, 199106, Russia
Mayville, Durban, KwaZulu-Natal 4091, South Africa
Pathumwan, Bangkok 10330, Thailand
Muang, Changwat Khon Kaen 40002, Thailand
Fatih / Istanbul, 34093, Turkey (Türkiye)
Gaziantep, 27310, Turkey (Türkiye)
Izmir, 35110, Turkey (Türkiye)
Chernivtsi, 58001, Ukraine
Chernivtsi, 58002, Ukraine
Dnipro, 49069, Ukraine
Ivano-Frankivsk, 76018, Ukraine
Ivano-Frankivsk, 76018, Ukraine
Kharkiv, 61002, Ukraine
Kharkiv, 61096, Ukraine
Kharkiv, 61124, Ukraine
Kyiv, 04050, Ukraine
Lviv, 79008, Ukraine
Poltava, 36011, Ukraine
Tarasove Village, 45625, Ukraine