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This is a prospective clinical study designed to assess blood loss in intracapsular and extracapsular hip fractures undergoing operative fixation at a Level II trauma center. It is well established in the orthopedic literature that tranexamic acid (TXA) decreases blood loss and need for postoperative blood transfusion in hip fracture patients as well as total joint arthroplasty patients. A typical dosing pattern, and the dosing pattern employed at our institution, is 1 gram IV infused prior to incision followed by 1 gram IV infused at the time of wound closure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Early Adminstration of TXA + Intraoperative TXA | Experimental | This group receives 1 G of TXA as soon as possible after a diagnosis of an acute hip fracture if the patient meets inclusion and exclusion criteria. The group will also receive 2 grams of TXA total intraoperatively. |
|
| Intraoperative only TXA | Other | This group will only receive the intraoperative TXA. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tranexamic acid | Drug | TXA to be given at time of diagnosis in the emergency department (ED) in treatment group and at time of operation for both groups |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Blood Transfusion | Patient receives a blood transfusion during their postoperative stay in the hospital | Up to two weeks |
| Overall Blood Loss | Calculate the difference in postoperative blood loss between groups | Up to two weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Length of hospital stay | Overall length of hospital stay | Up to two weeks |
| Postoperative Pain | Difference in overall pain scores between groups |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jacob Hinkley, DO, MS | Contact | 810-606-5669 | jacob.hinkley2@ascension.org | |
| Jacob Lytle, DO | Contact | 810-606-5669 | jacob.lytle@ascension.org |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ascension Genesys Hospital | Recruiting | Grand Blanc | Michigan | 48439 | United States |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jul 19, 2023 | Aug 9, 2023 | 1 |
| ID | Term |
|---|---|
| D019106 | Postoperative Hemorrhage |
| ID | Term |
|---|---|
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011183 | Postoperative Complications |
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| ID | Term |
|---|---|
| D014148 | Tranexamic Acid |
| ID | Term |
|---|---|
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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|
| Up to two weeks |
| Wound complications | Acute wound complications documented after surgical intervention | Up to two weeks |
| Acute DVT/PE | Documented deep venous thrombosis or pulmonary embolism | Up to two weeks |