Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
THRIVE and iGEL were applied for maintain oxygenation in bronchoscopic interventions which could not performed with an endotracheal tube. However, besides the risk of desaturation, the differences on difficulties to approach vocal cords, the responses to spay of local anesthetics including cough or spasm, the CO2 elimination, the hemodynamic changes, and the effects on postoperative recovery are rarely investigated.
THRIVE and iGEL were applied for maintain oxygenation in bronchoscopic interventions which could not performed with an endotracheal tube. Unlike the nasal cannula with THRIVE, the tips of iGel are located in upper esophagi, it may affect the postoperative swallowing, especially for the aged group. However, the bronchoscopic approach may be easier for an established route to vocal cords. With shared airway for ventilation and interventions, CO2 elimination is hardly monitored besides the risk of desaturation.
In this study, THRIVE or iGel was planned to be randomized used for bronchoscopic interventions in an adult group (age 20-65) and an aged group (age over 65). The difficulties to approach vocal cords, the responses to spay of local anesthetics including cough or spasm, the CO2 elimination, the hemodynamic changes, and the effects on postoperative recovery are compared between THRIVE and iGel groups.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high-flow nasal oxygen | Experimental | THRIVE( Transnasal humidified rapid-insufflation ventilatory exchange), a method of high-flow nasal oxygen (HFNO), is planned to applied for bronchoscopic interventions |
|
| supraglottic devise | Active Comparator | iGel, a supraglottic devise with tip in upper esophagus, is planned to applied for bronchoscopic interventions |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The responses to bronchoscopic insertion for bronchoscopic interventions such asTBNA, Cryotherapy, etc. | Procedure | cough response, the changes of BP, HR, SpO2, Trans dermal CO2 during bronchoscopic interventions |
| Measure | Description | Time Frame |
|---|---|---|
| difficulty of bronchoscopic approach | time from insertion to visualize vocal cord, records of manipulations if applied | from bronchoscopic insertion to visualize vocal cords |
| response to spraying local anesthetics by bronchoscopy | the status of vocal cords visualized (relaxed, closed, relaxed but close with spray of local anesthetics); cough scale during bronchoscopic insertion and spray of local anesthetics | from visualizng vocal cords to complete local anesthetic spray in trachea and main bronchi |
| Measure | Description | Time Frame |
|---|---|---|
| hemodynamic changes | changes on MAP (mmHg) | from bronchoscopic insertion to 20 minutes after completion of local anesthetic spraying |
| cough scale | cough intensity X times |
| Measure | Description | Time Frame |
|---|---|---|
| EAT-10 questionnaire (score):0-40 | EAT-10 for postbronchoscopic swallowing dysfunction, from 0 (normal swallowing) to 40 (extreme difficulty on swallowing) | preoperative and postoperative day 1 |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Fu-Chang Tsai | National Taiwan University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University Cancer Center | Taipei | Taiwan |
if there is similar investigation
1 year after completion of investigation
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D014133 | Tracheal Diseases |
| ID | Term |
|---|---|
| D012140 | Respiratory Tract Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D017679 | Cryotherapy |
| D006439 | Hemodynamics |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D002320 | Cardiovascular Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| postoperative recovery | Procedure | anesthetic recovery in postoperative care unit recovery of swallowing by questionnaire in POD1 |
|
| from bronchoscopic insertion to the end of procedure |
| SPO2 | pulse oximeter, hemoglobin saturation (%) | every 5 minutes from bronchoscopic insertion to the end of procedure |
| Transdermal CO2 | data obyenied from transdermal CO2 (mmHg) | every 5 minutes from bronchoscopic insertion to the end of procedure |
| postanesthetic recovery | time stay in postoperative care unit (minutes) | from admission to PACU to discharge from PACU |