The purpose of this study is to evaluate the genome-wide association for the development of collateral circulation for patients with coronary or peripheral artery disease and to develop the molecular genetic treatment model based on genome-wide association data.

Inclusion Criteria:

• Age more than 20
• Chronic total occlusive lesion from the coronary or peripheral angiogram

Exclusion Criteria:

• Renal dysfunction
• Hepatic dysfunction
• Thrombocythemia or thrombocythemia
• Planned major surgery in 1 year
• History of gastrointestinal haemorrhage
• Malignant tumor

Patients with chronic total coronary or peripheral occlusion