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The working hypothesis is that hypertension during the first post-transplant trimester is partly explained by the patient's hypervolemia. The main objective of the single-center observational study "HTA ô Connect" is to study the relationship between hypertension and extracellular hyperhydration, thanks to repeated self-measurements of blood pressure and impedancemetry between the 30th and the 90th day post-transplant, in 150 incident kidney transplant patients from our department, the ITUN (Institute of Urology-Nephrology Transplantation).
The study population involves 150 incident kidney transplant patients, presenting to the Nantes University Hospital Transplant Institute for 1 month (D30), and presenting with hypertension ≥ 140/90mmHg and not treated with a diuretic.
Data collected at the patients' homes will be used to establish a relationship between blood pressure and extracellular water volume. The data collected will not be used to follow up patients who participated in the study in this first stage of exploration.
Evaluation parameters
Blood pressure :
Weight :
Impedance measurement :
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Measurement of systolic and diastolic blood pressure, impedancemetry, weight, creatinemia and Pro-BNP measurements | Other | Measurement of systolic and diastolic blood pressure, impedancemetry, weight, creatinemia and Pro-BNP measurements At D30 and D90 Measurement of systolic and diastolic blood pressure, impedancemetry, weight, 3 times a week between D30 and D90 post-transplant, |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between Hypertension and extracellular hyperhydration | Hypertension will be assessed by measurement of blood pressure | Day 90 |
| Correlation between Hypertension and extracellular hyperhydration | Extracellular hyperhydration will be measured by impedance measurement | Day 90 |
| Measure | Description | Time Frame |
|---|---|---|
| hypertension measurement | Blood pressure : At inclusion and at the end of the study (in consultation at Day 30 and Day 90, respectively), blood pressure will be measured 3 times after a few minutes of rest in a sitting position Hypertension in consultation will be defined by values > 140/90 mmHg. • Between Day 30 and D90, blood pressure will be measured by self-measurement using DM-certified devices, 3 times in the morning at breakfast and in the evening before bedtime, in a sitting position after a few minutes of rest. The operation will be repeated 3 days a week (Monday to Wednesday) between the 30th and the 90th day post-transplant. Self-measurement hypertension will be defined by values > 135/85 mmHg. |
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Inclusion Criteria :
Exclusion Criteria :
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The study population involves 150 incident kidney transplant patients, presenting to the Nantes University Hospital Transplant Institute for 1 month (D30), and presenting with hypertension ≥ 140/90mmHg recorded in the outpatient clinic at the Nantes University Hospital, according to the recommendations of the French Society of Arterial Hypertension (6) and not treated with a diuretic.
There will be no emergency inclusion. Recently transplanted patients will come regularly, between 1 and 2 times per week, to the Nantes University Hospital during the first month. The study will be presented to them during this period and they will be included at the D30 (M1) consultation.
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| Name | Affiliation | Role |
|---|---|---|
| Claire GARANDEAU, PH | Nantes University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nantes University Hospital | Nantes | Loire-Atlantique | 44093 | France |
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| For 3 month post-transplant |
| Impedance measurement | At inclusion and at the end of the study in consultation, respectively at Day 30 and D90, impedancemetry will be measured once. • Between Day 30 and Day 90, impedancemetry measurements will be collected at the same time as blood pressure measurements at the patients' homes by self-measurement 3 times in the morning and 3 times in the evening, 3 days a week (from Monday to Wednesday) between the 30th and the 90th day after transplantation. | For 3 month post-transplant |
| Weight measurement | Weight will be measured only once at the inclusion consultation | day 30 |
| Weight measurement | Weight will be measured at the end of the study . | Day 90 |
| Weight measurement | The weight will be measured by self-measurement using DM certified scales. | 3 days a week between the 30th and the 90th day after transplantation. |
| Correlation between repeated systolic and diastolic blood pressure self-measurements and patient weight | blood pressure will be measured 3 times after a few minutes of rest in a sitting position Hypertension in consultation will be defined by values > 140/90 mmHg.
| Day 90 |
| Correlation between repeated self-measurements of extracellular hyperhydration | Impedance measurement | 3 times a week |
| Correlation between repeated self-measurements of extracellular hyperhydration | Weight | 3 times a week |
| Correlation between repeated self-measurement of systolic and diastolic blood pressure and creatinemia and pro-BNP blood | Composites criteria : Systolic and diastolic blood pressure will be assessed by measurement of blood pressure Plasma creatinine and proBNP will mesuread by a blood test | Day 90 |
| Correlation between repeated self-measurement of extracellular hyperhydration indices by impedancemetry and creatinemia and pro-BNP blood | Composites criteria : Extracellular hyperhydration will be measured by impedance measurement Plasma creatinine and proBNP will mesuread by a blood test | Day 90 |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| D004487 | Edema |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D001794 | Blood Pressure |
| D014894 | Weights and Measures |
| ID | Term |
|---|---|
| D055986 | Vital Signs |
| D010808 | Physical Examination |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006439 | Hemodynamics |
| D002320 | Cardiovascular Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |
| D008919 | Investigative Techniques |
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