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Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.The aim of this thesis study is to evaluate the effect of ProTaper Universal Retreatment (PTUR), Reciproc blue and XP-endo Finisher R file systems, which are used in the removal of root canal filling materials during retreatment with different motion kinetics on the release of Substance P, Calcitonin Gene-Related Peptide (CGRP), IL-6 and IL-10 inflammatory mediators in the periapical region
Seventy-five individuals with asymptomatic and chronic apical periodontitis teeth with retreatment indication were included in the study. Individuals were randomly divided into three groups according to the file system used to remove root canal filling materials (n = 25): ProTaper Universal Retreatment, Reciproc blue and XP-endo Finisher R.After the removal of the previous root canal filling materials, reshaping and disinfection of the root canals, periapical fluid samples were taken from the root tip of the teeth in all three groups. The amount of Substance P, CGRP, IL-6 and IL-10 mediators that cause pain, swelling and flare-up in periapical fluid samples were measured by ELISA test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Retreatment system using in rotational motion | Experimental | Previous root canal filling materials were removed with D1-D2-D3 retreatment files with using an endodontic motor in rotational motion |
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| Retreatment system using in reciprocal motion | Experimental | Previous root canal filling materials were removed with Reciproc 25 file with using an endodontic motor in reciprocal motion |
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| Retreatment system using in additional rotational motion | Experimental | Previous root canal filling materials were removed with XP-endo finisher r file with using an endodontic motor in rotational motion |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Protaper Universal Retreatment | Other | D1-D2-D3 Retreatment files were used in 500 rpm and 3 Ncm with X-Smart endomotor |
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| Measure | Description | Time Frame |
|---|---|---|
| change of inflammatory mediator level | The samples were collected from periapical exudate at the end of the root canal retreatment procedure. The samples were analyzed with ELISA method and change of inflammatory mediator levels were evaluated in pg/ml. | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sevinç Aktemur Türker | Bulent Ecevit University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Dentistry of Bulent Ecevit University | Zonguldak | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36856848 | Derived | Kasikci S, Turker SA, Guven B. Effect of different retreatment files using different kinematics on the release of inflammatory mediators in root canal retreatment of single-rooted teeth: a randomized clinical trial. Clin Oral Investig. 2023 Jun;27(6):3189-3196. doi: 10.1007/s00784-023-04930-6. Epub 2023 Mar 1. |
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| Reciproc | Other | R25 retratment files were used with X-Smart endomotor in reciprocal motion |
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| XP-Endo finisher R | Other | XP-Endo finisher r file were used in 1000 rpm 1 Ncm with X-Smart endomotor |
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