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While some investigators found oral metronidazole to be effective in reducing pain after hemorrhoidectomy, other researchers did not find a significant analgesic effect of systemic metronidazole. On the other hand, topical application of metronidazole had more consistent favorable results as Ala et al documented a remarkable analgesic effect of topical metronidazole 10% after excisional hemorrhoidectomy which was in line with Nicholson and Armestrong who also concluded similar results.
No previous study compared the analgesic effect of topical and oral metronidazole after anorectal surgery. Therefore, the present trial was conducted to compare the impact of oral versus systemic metronidazole on pain and recovery after surgery for benign anorectal conditions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Topical metronidazole | Active Comparator | Topical application of metronidazole cream on the anal verge after surgery |
|
| Oral metronidazole | Active Comparator | oral metronidazole 500 mg tablets after surgery |
|
| Control | No Intervention | No metronidazole was received |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Topical metronidazole | Drug | Topical application of metronidazole cream on the anal verge every 8 hours after surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative pain score | Pain was assessed using visual analogue scale form 0 to 10, higher score indicates worse pain | at one day after surgery |
| Postoperative pain score | Pain was assessed using visual analogue scale form 0 to 10, higher score indicates worse pain | at two days after surgery |
| Postoperative pain score | Pain was assessed using visual analogue scale form 0 to 10, higher score indicates worse pain | at seven days after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mansoura university hospital | Al Mansurah | Dakahlia Governorate | 35516 | Egypt |
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| ID | Term |
|---|---|
| D006484 | Hemorrhoids |
| D005401 | Fissure in Ano |
| D012003 | Rectal Fistula |
| ID | Term |
|---|---|
| D012002 | Rectal Diseases |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| ID | Term |
|---|---|
| D008795 | Metronidazole |
| ID | Term |
|---|---|
| D009593 | Nitroimidazoles |
| D009574 | Nitro Compounds |
| D009930 | Organic Chemicals |
| D007093 | Imidazoles |
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| oral metronidazole | Drug | Patients received oral metronidazole 500 mg tablets every 8 hours after surgery |
|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D001004 | Anus Diseases |
| D007412 | Intestinal Fistula |
| D016154 | Digestive System Fistula |
| D005402 | Fistula |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001393 |
| Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |