A Study to Evaluate GBT021601 in Single and Multiple Doses in Healthy Participants

A Double-Blind, Randomized, Placebo-Controlled, Single and Multiple Ascending Dose (SAD/MAD) Study to Evaluate the Safety, Tolerability, PK, and Food Effect of GBT021601, a Hemoglobin S Polymerization Inhibitor, in Healthy Participants.

This first in human study is designed to evaluate the safety, tolerability, pharmacokinetics (PK), and food effect of GBT021601, a hemoglobin S (HbS) polymerization inhibitor, in healthy participants.

This is a randomized, double-blind, placebo controlled, single and multiple ascending dose study in healthy participants.

Inclusion Criteria:

• Healthy males and females ≥ 18 to ≤ 55 years of age
• Body mass index ≥ 18.0 to ≤ 30.0 kg/m2
• Body weight ≥ 50 kg at screening and Day -1

Exclusion Criteria:

- Positive pregnancy test or currently breastfeeding.