A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty

A Phase 2, Randomized, Double-blind, Placebo-controlled, Multi-dose Study Evaluating the Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty

The purpose of this study is to evaluate the efficacy and safety of VX-548 doses in treating acute pain after an abdominoplasty.

Key Inclusion Criteria:

• Before Surgery:

  • Participant scheduled to undergo an abdominoplasty without collateral procedures

• After Surgery:

  • Participant is lucid and able to follow commands
  • All analgesic guidelines were followed during and after the abdominoplasty
  • Abdominoplasty procedure duration <=3 hours without collateral procedures (for example., liposuction)

Key Exclusion Criteria

• Before Surgery:

  • Prior history of abdominoplasty, intra-abdominal and/or pelvic surgery
  • History of cardiac dysrhythmias requiring anti-arrhythmia treatment(s)
  • Any prior surgery within 1 month before the first study drug

• After Surgery:

  • Participant had medical complications during the abdominoplasty that, in the opinion of the investigator, should preclude randomization
  • Participant had collateral procedures during the abdominoplasty

Other protocol defined Inclusion/Exclusion criteria may apply.