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This is a prospective randomized double-blind non-inferiority trial designed to test the hypothesis that erector spinae plane block (ESPB) is non-inferior to thoracic paravertebral block (TPVB) in postoperative pain control after pectus excavatum repair.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ESPB group | Experimental | 0.25% ropivacaine 0.5 ml/kg is injected at the fascial plane deep to the erector spinae muscle |
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| TPVB group | Active Comparator | 0.25% ropivacaine 0.5 ml/kg is injected into the thoracic paravertebral space (T5) using TPVB approach. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ESPB group | Procedure | A 21-gauge 100-mm needle will be inserted into the fascial layer beneath the iliocostalis, longissimus, and spinalis muscles. A bolus of 0.25% ropivacaine 0.5 ml/kg will be injected into the fascial layer. Contralateral ESPB will be performed similarly. |
| Measure | Description | Time Frame |
|---|---|---|
| Pain scores at rest at 24 hours postoperatively | Pain scores will be recorded using the Numeric Rating Scale (NRS) scores (0-10). | 24 hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| The pain degree at rest and after movement or coughing(dynamic) | The pain degree at rest and after movement or coughing at 3, 6, 12, 24, and 48 hours after surgery respectively. | at 3, 6, 12, 24, and 48 hours after surgery |
| total rescue morphine-equivalent consumption per weight |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jin Liu | Department of Anesthesiology, West China Hospital, Sichuan University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology, West China Hospital | Chengdu | Sichuan | 610041 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35164831 | Derived | Xu M, Zhang G, Gong J, Yang J. Comparison of erector spinae plane and paravertebral nerve blocks for postoperative analgesia in children after the Nuss procedure: study protocol for a randomized controlled non-inferiority clinical trial. Trials. 2022 Feb 14;23(1):139. doi: 10.1186/s13063-022-06044-y. |
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| ID | Term |
|---|---|
| D000377 | Agnosia |
| D005660 | Funnel Chest |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| TPVB group | Procedure | A 21-gauge 100-mm insulated needle will be inserted into the paravertebral space via an in-plane parasagittal approach. After perforating the costotransverse ligament, 0.25% ropivacaine 0.5 ml/kg will be injected. Anterior movement of the pleura indicated the appropriate spread of the local anesthetics in the paravertebral space. The process will be repeated on the contralateral side. |
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total rescue morphine-equivalent consumption per weight at predetermined time intervals (24 and 48 hours) after surgery |
| at 24 and 48 hours after surgery |
| Emergence agitation at 5, 15, 30 min after extubation | Emergence agitation will be registered using pediatric anesthesia emergence delirium (PAED) at 5, 15, 30 min after extubation | at 5, 15, 30 min after extubation |
| Total dosage of intraoperative sufentanil and remifentanil | Total dosage of intraoperative sufentanil and remifentanil per weight | during surgery |
| The time to first analgesia request | Time from operation to first rescue analgesia request | within the 3 days after surgery |
| The time to first mobilization | Time from operation to ambulation | within the 3 days after surgery |
| Side effects | Side effects such as pneumothorax, local anesthetic toxicity, postoperative nausea and vomiting | within the 5 days after surgery |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001848 | Bone Diseases, Developmental |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D009139 | Musculoskeletal Abnormalities |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |