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This study aims to investigate the effect of a 15-minute meditation practice on sleep architecture and high-frequency Heart Rate Variability (HF-HRV), as well as cognitive performance after both a well-rested and sleep-deprived night.
Sleep is physiologically important for memory consolidation, mood and hormonal regulation, and maintaining low levels of systemic inflammation. However, a substantial proportion of people are reported to regularly sleep less than the recommended 7-9 hours a night. Meditation may be a means to mitigate the negative effects of sleep deprivation, as many types of meditations are associated with increasing high-frequency heart rate variability (HF-HRV), which is an index of parasympathetic control of the heart. Greater parasympathetic drive may be associated with physiological buffering of the detrimental effects of sleep deprivation.
The investigators want to conduct a prospective cohort study where subjects practice a 15-minute meditation (Shoonya meditation) or continue their usual routine. Subjects will be asked to complete some cognitive tests before and after a night of sleep and a night of sleep deprivation. During the night of sleep, participants will undergo polysomnography recording for sleep architecture and quality.
The intervention group and the control group, which continues their usual routine, will only undergo one visit.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nap Practitioners | This is an observational arm of regular nappers. Individuals that take naps at least two times a week will be invited to undergo all of the study procedures for one weekend of data collection. |
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| Shoonya Meditators | This is intervention arm. Participants will learn and practice the fifteen minute shoonya meditation - described as a process of conscious non-doing- and shakti chalana kriya, which is a set of breathing exercises designed as a preparatory practice to shoonya meditation. Participants will practice shoonya meditation twice a day for two months. A weekend of data collection will happen at baseline and two months after they learn the practice. |
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| Control Meditators | Control subjects will be individuals that have learned the prerequisite meditation to Shoonya meditation. This meditation is called Shambhavi Mahamudra Kriya. Control subjects will not learn Shoonya meditation while they are participating in the study. One weekend of data collection will occur at baseline. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nap Practitioners | Behavioral | Regular nappers will be given a 30 minute nap opportunity to nap for as long as they please. |
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| Measure | Description | Time Frame |
|---|---|---|
| Error frequency Change: Go-No Go Task | The primary outcome is the difference in number of commission and omission errors on the Go-No Go task. The difference in scores pre- and post-sleep deprivation will be analyzed between the control and intervention group. | 2 months post learning meditation |
| Measure | Description | Time Frame |
|---|---|---|
| Reaction Time Change: Go-No Go | The difference in reaction times on the Go-No Go task. The difference in scores pre- and post-sleep deprivation will compared between the control and intervention groups. | 2 months post learning meditation |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy adults recruited from across the United States.
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| Name | Affiliation | Role |
|---|---|---|
| Balachundhar Subramaniam, MD, MPH | Beth Israel Deaconess Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beth Israel Deaconess Medical Centre | Boston | Massachusetts | 02215 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29132973 | Background | Heyde I, Kiehn JT, Oster H. Mutual influence of sleep and circadian clocks on physiology and cognition. Free Radic Biol Med. 2018 May 1;119:8-16. doi: 10.1016/j.freeradbiomed.2017.11.003. Epub 2017 Nov 10. | |
| 29073412 | Background | Hirshkowitz M, Whiton K, Albert SM, Alessi C, Bruni O, DonCarlos L, Hazen N, Herman J, Katz ES, Kheirandish-Gozal L, Neubauer DN, O'Donnell AE, Ohayon M, Peever J, Rawding R, Sachdeva RC, Setters B, Vitiello MV, Ware JC, Adams Hillard PJ. National Sleep Foundation's sleep time duration recommendations: methodology and results summary. Sleep Health. 2015 Mar;1(1):40-43. doi: 10.1016/j.sleh.2014.12.010. Epub 2015 Jan 8. |
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| ID | Term |
|---|---|
| D012892 | Sleep Deprivation |
| D012893 | Sleep Wake Disorders |
| ID | Term |
|---|---|
| D020920 | Dyssomnias |
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
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| Shoonya Meditation | Behavioral | This is a 15 minute meditation, described as a process of conscious non-doing. |
|
| 31685950 | Background | Ben Simon E, Rossi A, Harvey AG, Walker MP. Overanxious and underslept. Nat Hum Behav. 2020 Jan;4(1):100-110. doi: 10.1038/s41562-019-0754-8. Epub 2019 Nov 4. |
| 28515433 | Background | Krause AJ, Simon EB, Mander BA, Greer SM, Saletin JM, Goldstein-Piekarski AN, Walker MP. The sleep-deprived human brain. Nat Rev Neurosci. 2017 Jul;18(7):404-418. doi: 10.1038/nrn.2017.55. Epub 2017 May 18. |
| 25783612 | Background | Tang YY, Holzel BK, Posner MI. The neuroscience of mindfulness meditation. Nat Rev Neurosci. 2015 Apr;16(4):213-25. doi: 10.1038/nrn3916. Epub 2015 Mar 18. |
| 28118405 | Background | Braboszcz C, Cahn BR, Levy J, Fernandez M, Delorme A. Increased Gamma Brainwave Amplitude Compared to Control in Three Different Meditation Traditions. PLoS One. 2017 Jan 24;12(1):e0170647. doi: 10.1371/journal.pone.0170647. eCollection 2017. |
| 20670413 | Background | Kaul P, Passafiume J, Sargent CR, O'Hara BF. Meditation acutely improves psychomotor vigilance, and may decrease sleep need. Behav Brain Funct. 2010 Jul 29;6:47. doi: 10.1186/1744-9081-6-47. |
| 27055575 | Background | Maruthai N, Nagendra RP, Sasidharan A, Srikumar S, Datta K, Uchida S, Kutty BM. Senior Vipassana Meditation practitioners exhibit distinct REM sleep organization from that of novice meditators and healthy controls. Int Rev Psychiatry. 2016 Jun;28(3):279-87. doi: 10.3109/09540261.2016.1159949. Epub 2016 Apr 8. |
| 21075236 | Background | Killgore WD. Effects of sleep deprivation on cognition. Prog Brain Res. 2010;185:105-29. doi: 10.1016/B978-0-444-53702-7.00007-5. |
| 18771686 | Background | Thayer JF, Lane RD. Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration. Neurosci Biobehav Rev. 2009 Feb;33(2):81-8. doi: 10.1016/j.neubiorev.2008.08.004. Epub 2008 Aug 13. |
| 28912591 | Background | Lischke A, Lemke D, Neubert J, Hamm AO, Lotze M. Inter-individual differences in heart rate variability are associated with inter-individual differences in mind-reading. Sci Rep. 2017 Sep 14;7(1):11557. doi: 10.1038/s41598-017-11290-1. |
| 33306103 | Background | Kong SDX, Hoyos CM, Phillips CL, McKinnon AC, Lin P, Duffy SL, Mowszowski L, LaMonica HM, Grunstein RR, Naismith SL, Gordon CJ. Altered heart rate variability during sleep in mild cognitive impairment. Sleep. 2021 Apr 9;44(4):zsaa232. doi: 10.1093/sleep/zsaa232. |
| 22457646 | Background | Libby DJ, Worhunsky PD, Pilver CE, Brewer JA. Meditation-induced changes in high-frequency heart rate variability predict smoking outcomes. Front Hum Neurosci. 2012 Mar 19;6:54. doi: 10.3389/fnhum.2012.00054. eCollection 2012. |
| 32020660 | Background | Koerten HR, Watford TS, Dubow EF, O'Brien WH. Cardiovascular effects of brief mindfulness meditation among perfectionists experiencing failure. Psychophysiology. 2020 Apr;57(4):e13517. doi: 10.1111/psyp.13517. Epub 2020 Feb 4. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D001523 | Mental Disorders |