Evaluation of the Incidence of NTRK Gene Fusion in Adult Brain Tumours

Evaluation of the Incidence of NTRK Gene Fusion in Adult Brain Tumours

This is a retrospective, mono centric, exploratory study to assess the incidence of a genomic alteration: NTRK gene fusion, in adult gliomas and brain metastases.

Retrospective mono centric study of medical data (clinical, histological, molecular and imaging) from medical records and analysis of available excisional tissue samples.

Inclusion Criteria:

• Adult male or female subject;
• Glioma or brain metastasis operated on in our institution, histologically confirmed (WHO classification 2016);
• Subject with a frozen tumour sample < 5 years old;
• Subject for whom all clinico-radiological data are available;
• Subject affiliated to a health insurance scheme;
• Subject who has been informed of the research and who has not indicated his opposition to the use of his medical data and who has signed a consent for the use of his tumour sample.

Exclusion Criteria:

• Patient under legal protection, guardianship or deprived of liberty by judicial or administrative decision
• Biological samples not available and/or in insufficient quantity for analysis