Evaluate the safety and effectiveness of iSTAR Medical's MINIject™ implant for lowering intraocular pressure (IOP) in subjects with primary open-angle glaucoma.

This is a prospective, multicenter, masked clinical trial to evaluate the safety and effectiveness of iSTAR Medical's MINIject™ implant for lowering intraocular pressure (IOP) in subjects with primary open-angle glaucoma.

Key Inclusion Criteria:

• Males and females, 46 years of age or older
• A diagnosis of primary open-angle glaucoma, who are candidates for medical therapy, laser treatment, or glaucoma-filtering surgery
• Pseudophakic with prior uncomplicated cataract surgery

Key Exclusion Criteria:

• Angle closure, congenital, or secondary glaucoma
• Diagnosed degenerative visual disorders
• Clinically significant intraocular inflammation or infection

Person(s) checking intraocular pressures are masked, except for day of surgery, throughout the duration of the trial.