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Minimal flow anesthesia has economic and environmental advantages in addition to providing earlier recovery following general anesthesia. There is a paucity of data concerning the effect of minimal flow anesthesia (fresh gas flow <0,5 l/min) on recovery parameters. The primary objective of this study is to compare the recovery parameters of desflurane and sevoflurane in minimal flow anesthesia while the secondary objective is to compare the effect of these agents on anesthetic depth using bispectral index.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group Sevoflurane | Active Comparator | The patients in this arm will be given Sevoflurane (2-3%) as volatile anesthetic throughout the duration of anesthesia. |
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| Group Desflurane | Active Comparator | The patients in this arm will be given Desflurane (7-8%) as volatile anesthetic throughout the duration of anesthesia. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Sevoflurane | Procedure | Sevoflurane will be used for the maintenance of general anesthesia which will be carried out using a fresh gas flow of less than 0,5 l/min |
| Measure | Description | Time Frame |
|---|---|---|
| Time until extubation | Time interval between discontinuation of the volatile anesthetics and removal of the endotracheal tube | Up to 10 minutes after discontinuation of the volatile anesthetic |
| Time until eye opening | Time interval between discontinuation of the volatile anesthetics and eye opening with verbal command | Up to 20 minutes after discontinuation of the volatile anesthetic |
| Time until transfer readiness | Time interval between discontinuation of the volatile anesthetics and Aldrete score reaching 9 or greater | Up to 45 minutes after discontinuation of the volatile anesthetic |
| Measure | Description | Time Frame |
|---|---|---|
| Anesthetic depth provided by the volatile anesthetic | Anesthetic depth as measured by Bispectral Index | Change in Bispectral Index values at 5, 10, 15, 30, 60 and 120 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Baturay K Kazbek, Ass. Prof. | Contact | +903122044000 | 4099 | bkkazbek@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Baturay K Kazbek, Ass. Prof. | Ufuk University Faculty of Medicine Department of Anesthesiology and Reanimation | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ufuk University Dr. Rıdvan Ege Hospital | Recruiting | Ankara | 06520 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33103139 | Background | Taskin D, Gedik E, Kayhan Z. Effects of Minimal Flow Sevoflurane or Desflurane Anaesthesia on Hemodynamic Parameters, Body Temperature and Anaesthetic Consumption. Turk J Anaesthesiol Reanim. 2020 Oct;48(5):356-363. doi: 10.5152/TJAR.2020.39699. Epub 2020 May 5. | |
| 26579522 | Background | Werner JG, Castellon-Larios K, Thongrong C, Knudsen BE, Lowery DS, Antor MA, Bergese SD. Desflurane Allows for a Faster Emergence When Compared to Sevoflurane without Affecting the Baseline Cognitive Recovery Time. Front Med (Lausanne). 2015 Oct 28;2:75. doi: 10.3389/fmed.2015.00075. eCollection 2015. |
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| Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Desflurane | Procedure | Desflurane will be used for the maintenance of general anesthesia which will be carried out using a fresh gas flow of less than 0,5 l/min |
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