Insufficient accrual. Recruitment was stopped because enrollment targets were unlikely to be achieved. A total of 505 of 600 planned participants were enrolled. Data will be included in planned pooled analyses.

Biopsies are performed in several autoimmune diseases to diagnose or classify them Tolerance and information of the patients have been poorly evlauated our objective is to evaluate tolerance and information of the patients after the biopsies for salivary gland, temporal arteries and neuromuscular.

patinets that benefited of arterial temporal biospy or salivary gland biospy or muscuar biopsy or neuro muscular biospy for his auto -mmune disease will be included and fill standardized questionnaires concerning tolerance, information and side effect at inclusion , day 7 and day 30 after the biopsy data will be analysed to evaluate information, tolerance and risk factor af side effect

Inclusion Criteria:

• biospy required for the diagnsis or follow up aged of more than 18 non opposition form

Exclusion Criteria:

• unable to consent demencia unable to fill the form and questionnaire patient Under juridical protection refusing to participate

all patients that underwent a biospy for his auto-immune rare disease

All collected data that underlie results in a publication

Data will be available beginning one year and ending five years following the publication

Data access requests will be reviewed by the internal committee of Brest UH. Requestors will be required to sign and complete a data access agreement.