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The aim of the present study is the prospective controlled use of physical activity in a collective of patients with glioblastoma after surgery and concomitant radiation/chemotherapy and during adjuvant cytotoxic therapy. The research question is whether physical exercise is feasible and whether patients benefit physically and mentally from the activities performed. For this purpose, specific training units under the supervision of a certified trainer and sports scientist as well as standardized sports medical test procedures are implemented. Beyond the instructed training, general physical activity phases are recorded electronically using a pedometer/activity tracker, which is worn at all times.
It will be examined whether the individual training program
The measurements should be taken before and 8, 16 and 24 weeks after the start of training.
The personal trainers of the university clinics in Bochum and Homburg/Saar receive specific training activities from Münster's trainer Ralf Brandt in order to ensure a standardized concept. This way, a comparison of the trainings' conduction and recording is possible both quantitatively and qualitatively.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients paticipating in the Personal Training Program | Experimental | The study patients complete two training sessions per week (60 minutes each) under supervision (16 weeks) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Personal Training Program | Other | One training sessions includes an interval training on a bicycle ergometer. The second one is a strength training with exercise machines. Both trainings are supplemented by coordinative aspects. |
| Measure | Description | Time Frame |
|---|---|---|
| Increase in Physical Performance according to Physical Work Capacity (PWC) Test | Evidence of a significant increase (at least 15%) in physical work [watt/kilogram bodyweight] at PWC75% of maximum heart rate. | Between week 0 and 16. |
| Measure | Description | Time Frame |
|---|---|---|
| Physical Work Capacity (PWC) | PWC stratified according to:
| Between week 0 and 16 (and 24). |
| PWC |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dorothee Wiewrodt, PD Dr. med. | Universitätsklinikum Münster | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitätsklinikum Münster | Münster | North Rhine-Westphalia | 48149 | Germany |
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| ID | Term |
|---|---|
| D005909 | Glioblastoma |
| ID | Term |
|---|---|
| D001254 | Astrocytoma |
| D005910 | Glioma |
| D018302 | Neoplasms, Neuroepithelial |
| D017599 | Neuroectodermal Tumors |
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changes over time, follow-up
| after 8, 16 and 24 weeks |
| Spiroergometry - maximal oxygen consumption (VO2max) | Changes in the maximal oxygen consumption (measured during spiroergometry) | Between week 0 and 16 (and 24). |
| Spiroergometry - lactate | Changes in the individual anaerobic lactate threshold (measured during spiroergometry) | Between week 0 and 16 (and 24). |
| EORTC-QLQ-C30 Brain module | Changes in Health Related Quality of Life (HRQoL) using a standardized questionnaire; The EORTC QLQ-C30 questionnaire contains 30 questions and assesses the quality of life of oncology patients multidimensionally across 10 subscales. Times of measurement in week 0, 4, 8, 16, 20 and 24. | Between week 0 and 16 (and 24). |
| Distress Thermometer (DT) | Changes in Health Related Quality of Life (HRQoL) using a standardized questionnaire; scale from 1 (not stressed at all) to 10 (extremly stressed); Times of measurement in week 0, 4, 8, 16, 20 and 24. | Between week 0 and 16 (and 24). |
| Hospital Anxiety and Depression Scale (HADS) | Changes in Health Related Quality of Life (HRQoL) using a standardized questionnaire; The Hospital Anxiety and Depression Scale (HADS) is a self-rating scale developed to assess psychological distress in non-psychiatric patients. It consists of two subscales, anxiety and depression (14 items); Times of measurement in week 0, 4, 8, 16, 20 and 24. | Between week 0 and 16 (and 24). |
| D009373 |
| Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009380 | Neoplasms, Nerve Tissue |