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The aim of this project is to provide personalized multi-peptide vaccination in combination with the TLR1/2 ligand XS15 to individual patients with advanced solid and hematological malignancies without any approved treatment options.
Ethics: Patient treatment will be conducted according to §13 Absatz 2b, AMG.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Personalized multi-peptide vaccine | Biological | Peptide vaccine: Personalized multi-peptide vaccine cocktails consisting of 200-300µg each of 1-10 tumor-associated peptides selected individually based on the patient-individual HLA allotypes and HLA ligandome analysis of tumor cells Peptides are synthesized in the GMP-certified Wirkstoffpeptidlabor at the University of Tübingen and will be formulated at the GMP-Center of the University Hospital Tübingen. Peptides will be administered subcutaneously (s.c.) together with the TLR1/2 ligand XS15 emulsified in Montanide ISA 51 VG as adjuvant. Vaccination will take place every 6 weeks. A total of two to five vaccinations are planned. Treatment schedule: Vaccination will take place every 6 weeks. A total of two to five vaccinations are planned, depended on the induction of peptide-specific T-cell responses. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Juliane S Walz, MD | Contact | 07071/2968746 | kketi@med.uni-tuebingen.de | |
| Helmut R Salih, MD | Contact | 07071/2968746 | kketi@med.uni-tuebingen.de |
| Name | Affiliation | Role |
|---|---|---|
| Helmut R Salih, MD | CCU Translational Immunology, University Hospital Tübingen, Germany | Study Chair |
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| Label | URL |
|---|---|
| Department CCU Translational Immunology | View source |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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