Neuroendocrine Neoplasms Methylation Based Classifier - The NEMESIs-study

Neuroendocrine Neoplasms Methylation Based Classifier - The NEMESIs-study

Neuroendocrine neoplasms (NEN) are rare tumors that mainly occur in the gastrointestinal tract and the lungs. The currently available diagnostic and prognostic markers do not adequately represent the diversity of these tumors. Methylation analyzes of the tumor DNA represent a new, promising approach.

The aim of this project is therefore to improve the diagnostic and prognostic evaluation of neuroendocrine neoplasms by means of methylation analysis of the tumor DNA. On the one hand, existing tumor samples from the biobank of Basel University Hospital are evaluated, on the other hand, patients who are undergoing an operation will be prospectively inquired

Inclusion Criteria:

• neuroendocrine tumor

Exclusion Criteria:

• insufficient amount or quality of neuroendocrine tumor sample