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This is a prospective, random controlled trial(RCT) study. 430 patients undergoing coronary artery bypass grafting were enrolled. Our new way of cardiac denervation, defined as excision of Marshall ligament and Waterstone fat pad, was performed in 215 patients, and the other 215 patients were used as control subjects. All the patients need to equip with electronic monitor to record heart rhythms within 6 days after CABG. The investigators will compare the incidence of postoperative atrial fibrillation between two groups, and follow up 30 days after discharged.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cardiac denervation group | Experimental | In this group, patients undergoing CABG will receive the procedure of our new way of cardiac denervation, excision of Marshall ligament and Waterstone fat pad. |
|
| controlled group | No Intervention | In this group ,patients undergoing CABG will not receive the procedure of cardiac denervation. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cardiac denervation | Procedure | Excision of Marshall ligament and Waterstone fat pad during CABG. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of POAF during hospital. | Incidence of postoperative atrial fibrillation after surgery during hospital. | 6 days after surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of massive haemorrhage needing blood transfusion caused by cardiac denervation. | The incidence of massive haemorrhage needing blood transfusion caused by cardiac denervation during in-hospital time. | Postoperative hospitalization, an average of 8 days. |
| Incidence of transferring to on-pump CABG caused by cardiac denervation. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wei Feng, MD PhD | Chinese Academy of Medical Sciences, Fuwai Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College | Beijing | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39550720 | Derived | Yang Z, Tiemuerniyazi X, Xu F, Wang Y, Sun Y, Yan P, Tian L, Han C, Zhang Y, Pan S, Hu Z, Li X, Zhao W, Feng W. Partial Cardiac Denervation to Prevent Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: The pCAD-POAF Randomized Clinical Trial. JAMA Cardiol. 2025 Jan 1;10(1):71-77. doi: 10.1001/jamacardio.2024.4639. |
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The incidence of transferring to on-pump CABG caused by cardiac denervation during in-hospital time. |
| Intraoperatively. |
| Incidence of re-operation aiming to stop bleeding caused by cardiac denervation. | The incidence of re-operation aiming to stop bleeding caused by cardiac denervation during in-hospital time. | Postoperative hospitalization, an average of 8 days. |
| Incidence of pericarial effusion within 30 days after discharged. | The incidence of pericarial effusion within 30 days after discharged. | within 30 days after discharged. |
| Incidence of arrhythmia exclude of AF within 30 days after discharged. | The incidence of arrhythmia exclude of AF within 30 days after discharged. | within 30 days after discharged. |
| Postoperative length of hospitalization. | Each participant's oostoperative length of hospitalization. | Postoperative hospitalization, an average of 8 days. |
| All cost after surgery. | All cost associated with treatment after surgery during in-hospital time. | Postoperative hospitalization, an average of 8 days. |
| MACCE | major adverse cardiovascular and cerebrovascular events (MACCE), which was defined as the composite of stroke, myocardial infarction, repeat coronary revascularization and all-cause mortality during the 30-day follow-up. | within 30 days after discharged. |