The aim of the trial is to determine if the SYNBIOTIC (prebiotic and probiotic), provided twice daily (capsule) will help support skeletal health in otherwise healthy postmenopausal women in the early years postmenopause (1-6 years post last menstruation) over a 12-month period.

Inclusion Criteria:

• Written informed consent
• Stated availability throughout entire study period (12 months) and willingness to fulfill all details of the protocol
• In early postmenopause (at least 1 year but a maximum of 6 years since the last menstruation)
• At least 6-months since the last intake of hormone replacement therapy
• Dual energy X-ray absorptiometry (DXA)-derived Bone Mineral Density (BMD) T-score of greater than -2.5 at the lumbar spine (L1-L4), femoral neck, and total hip but no site with BMD ≤ -2.5
• Body Mass Index between 18.5 and 35 kg/m2
• Normal levels of serum calcium (<11mg/dL)
• Normal cardiovascular parameters (systolic blood pressure ≤ 155 mm Hg, diastolic blood pressure ≤ 95 mm Hg) healthy and medication controlled

Exclusion Criteria:

The presence of any of the following criteria will exclude the participant from participating in the study:

• History of other bone disorders (eg. Paget's disease, or osteomalacia, osteogenesis imperfecta, osteopetrosis, osteoporosis, etc.)
• Women who have had cancer and were treated with radiation therapy, anti-estrogen therapy, hormonal therapy, or aromatase inhibitors
• Any history of bone or colon cancer
• Autoimmune disorders (rheumatoid arthritis, Hashimoto's disease, Graves' disease, ect), uncontrolled type 2 diabetes, gastrointestinal disorders (ulcerative colitis, Crohn's disease, inflammatory bowel disease, irritable bowel syndrome), kidney disease or dysfunction or any other medical condition that could interfere with the conduct of the study.
• History of chronic antibiotic use
• History of bariatric surgery
• History of partial colectomy
• Women with spine abnormalities that would prohibit assessment of BMD
• Women who have undergone hip joint replacement
• Women who have undergone a partial hysterectomy
• Women with untreated hyperparathyroidism
• Women previously treated with calcitonin, estrogens, estrogen derivatives, selective estrogen receptor modulators (SERMs), tibolone, progestins, anabolic steroids, or daily glucocorticoids in the past 6 months
• Women treated with bisphosphonates or strontium in the past 5 years
• Women previously treated with PTH, PTH analogs, gallium nitrate, romosozumab or denosumab
• Per-oral use of corticosteroids
• Smoking or use of nicotine products within the past 6-months
• Any disease, that by the investigator's judgement, could interfere with the intestinal barrier function
• Participation in other bone, diet, autoimmune, or gastrointestinal related clinical trials in the last 6 months
• Desire and/or plans on changing current diet and/or exercise regime during the participation of this trial
• Pregnancy or lactation
• Consumption of dietary supplements (probiotics, prebiotics) in the month prior to or during study (if participant is willing to stop taking these for 1-month, they can be enrolled after a 1-month washout period)
• Consumption of antibiotics in the past 2 months (if participant is placed on an antibiotic after enrolment in the study, will be subject to a per protocol analysis)