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| ID | Type | Description | Link |
|---|---|---|---|
| 2021-A00670-41 | Other Identifier | ANSM |
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| Name | Class |
|---|---|
| Institut National de la Santé Et de la Recherche Médicale, France | OTHER_GOV |
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Cell-based immune therapy using modified macrophages is a promising therapeutic approach in breast cancer. The objective of this cohort study is to collect tumor samples to develop patients' derived organoids to test the antitumor activity of newly developed CAR-macrophages. Other biological samples will be collected such as blood to analyze the host inflammatory status.
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| Measure | Description | Time Frame |
|---|---|---|
| Antitumor activity of the CAR-macrophages against organoids from HER2 negative, HER2 low and HER2 positive breast cancers | Measurement of the phagocytic capacity | 24 months |
| Antitumor activity of the CAR-macrophages compared to non-modified macrophages | Measurement of the phagocytic capacity | 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Antitumor activity of the CAR-macrophages against organoids from early and advanced breast cancers patients | Measurement of the phagocytic capacity | 24 months |
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This is a cohort study conducted in breast cancer patients requiring a surgery or a tumor biopsy as part of their care.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nawale HAJJAJI, MD PhD | Contact | +33 320295910 | n-hajjaji@o-lambret.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oscar Lambret Center | Recruiting | Lille | 59000 | France |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| D017437 |
| Skin and Connective Tissue Diseases |