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To observe the effectiveness and safety of different therapies-non-vitamin K antagonist oral anticoagulants (NOACs) or vitamin K antagonists (VKAs) or antiplatelet agents and non-antithrombotic therapy - for the treatment of VT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| non-vitamin K antagonist oral anticoagulants (NOACs) |
| ||
| vitamin K antagonists (VKAs) |
| ||
| antiplatelet agents |
| ||
| non-antithrombotic therapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| non-vitamin K antagonist oral anticoagulants (NOACs) | Drug | Collecting information of patients with VT who received NOACs |
|
| Measure | Description | Time Frame |
|---|---|---|
| Thrombus resolution in 12 weeks follow-up | Thrombus resolution in 12 weeks follow-up | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Thrombus resolution in 6 weeks follow-up | Thrombus resolution in 6 weeks follow-up | 6 weeks |
| Thrombus resolution in 6 months follow-up | Thrombus resolution in 6 months follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who had a diagnosis of VT in Fuwai Hospital, National Center of Cardiovascular Diseases in China from July 2010 through March 2022.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Qing Yang | Recruiting | Beijing | 100000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24485697 | Background | Gianstefani S, Douiri A, Delithanasis I, Rogers T, Sen A, Kalra S, Charangwa L, Reiken J, Monaghan M, MacCarthy P. Incidence and predictors of early left ventricular thrombus after ST-elevation myocardial infarction in the contemporary era of primary percutaneous coronary intervention. Am J Cardiol. 2014 Apr 1;113(7):1111-6. doi: 10.1016/j.amjcard.2013.12.015. Epub 2014 Jan 14. | |
| 2643772 |
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| vitamin K antagonists (VKAs) | Drug | Collecting information of patients with VT who received VKAs |
|
| antiplatelet agents | Drug | Collecting information of patients with VT who received antiplatelet agents |
|
| non-antithrombotic therapy | Other | Collecting information of patients with VT without any antithrombotic therapy |
|
| 6 months |
| Thrombus resolution in 12 months follow-up | Thrombus resolution in 12 months follow-up | 12 months |
| Thromboembolism events | Thromboembolism events | 12 months |
| Bleeding | Bleeding | 12 months |
| All-cause death | All-cause death | 12 months |
| Background |
| Turpie AG, Robinson JG, Doyle DJ, Mulji AS, Mishkel GJ, Sealey BJ, Cairns JA, Skingley L, Hirsh J, Gent M. Comparison of high-dose with low-dose subcutaneous heparin to prevent left ventricular mural thrombosis in patients with acute transmural anterior myocardial infarction. N Engl J Med. 1989 Feb 9;320(6):352-7. doi: 10.1056/NEJM198902093200604. |
| 30587707 | Background | Abdelnaby M, Almaghraby A, Abdelkarim O, Saleh Y, Hammad B, Badran H. The role of rivaroxaban in left ventricular thrombi. Anatol J Cardiol. 2019 Jan;21(1):47-50. doi: 10.14744/AnatolJCardiol.2018.48313. No abstract available. |
| 22922416 | Background | Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC); Steg PG, James SK, Atar D, Badano LP, Blomstrom-Lundqvist C, Borger MA, Di Mario C, Dickstein K, Ducrocq G, Fernandez-Aviles F, Gershlick AH, Giannuzzi P, Halvorsen S, Huber K, Juni P, Kastrati A, Knuuti J, Lenzen MJ, Mahaffey KW, Valgimigli M, van 't Hof A, Widimsky P, Zahger D. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2012 Oct;33(20):2569-619. doi: 10.1093/eurheartj/ehs215. Epub 2012 Aug 24. No abstract available. |
| 32355836 | Background | He J, Ge H, Dong JX, Zhang W, Kong LC, Qiao ZQ, Zheng Y, Ding S, Wan F, Shen L, Wang W, Gu ZC, Yang F, Li Z, Pu J. Rationale and design of a prospective multi-center randomized trial of EARLY treatment by rivaroxaban versus warfarin in ST-segment elevation MYOcardial infarction with Left Ventricular Thrombus (EARLY-MYO-LVT trial). Ann Transl Med. 2020 Mar;8(6):392. doi: 10.21037/atm.2020.02.117. |
| 32598904 | Background | Guddeti RR, Anwar M, Walters RW, Apala D, Pajjuru V, Kousa O, Gujjula NR, Alla VM. Treatment of Left Ventricular Thrombus With Direct Oral Anticoagulants: A Retrospective Observational Study. Am J Med. 2020 Dec;133(12):1488-1491. doi: 10.1016/j.amjmed.2020.05.025. Epub 2020 Jun 27. |
| 39077494 | Derived | Yang Q, Liang Y, Quan X, Lang X, Gao D. Characteristics of Novel Anticoagulants versus Vitamin K Antagonists in the Ventricular Mural Thrombus. Rev Cardiovasc Med. 2023 Mar 2;24(3):74. doi: 10.31083/j.rcm2403074. eCollection 2023 Mar. |
| 39076670 | Derived | Yang Q, Quan X, Lang X, Liang Y. Predicting Thromboembolism in Hospitalized Patients with Ventricular Thrombus. Rev Cardiovasc Med. 2022 Nov 30;23(12):390. doi: 10.31083/j.rcm2312390. eCollection 2022 Dec. |
| 35685496 | Derived | Yang Q, Lang X, Quan X, Gong Z, Liang Y. Different Oral Antithrombotic Therapy for the Treatment of Ventricular Thrombus: An Observational Study from 2010 to 2019. Int J Clin Pract. 2022 Feb 24;2022:7400860. doi: 10.1155/2022/7400860. eCollection 2022. |
| ID | Term |
|---|---|
| C008208 | acarboxyprothrombin |
| D010975 | Platelet Aggregation Inhibitors |
| ID | Term |
|---|---|
| D006401 | Hematologic Agents |
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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