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The aim of our study is to evaluate the effect of magnesium on the hypnotic effect of propofol.
The aim of our study is to evaluate the effect of magnesium on the hypnotic effect of propofol. To achieve this, the investigators will analyse the effect of magnesium on the brain concentrations of propofol required to achieve a State Entropy value between 50-60, which corresponds to the recommended depth of anaesthesia. Our study will also evaluate the intraoperative anti- nociceptive effect of magnesium using pupillometry and its two indices, PPI and PRD
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Magnesium sulfate IV | Active Comparator | 10 patients scheduled for thyroidectomy |
|
| Placebo | Placebo Comparator | 10 patients scheduled for thyroidectomy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnesium sulfate IV | Drug | Infusion of magnesium sulphate 50 mg/kg (eq. 0.5ml/kg of magnesium sulphate 100mg/ml) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Propofol target concentration | The target concentration of Propofol TCI (target-control infusion) to achieve a state entropy value between 50-60 | through study completion, an average of 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Morphine consumption | Morphine consumption titrated in the recovery room and morphine equivalents claimed during the first 24 hours postoperatively | through study completion, an average of 3 months |
| PPI Measure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pierre-Yves Hardy, MD | Contact | 003242844858 | pyhardy@chuliege.be |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Liege, | Liège | 4000 | Belgium |
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Double blinded prospective randomized controlled trial
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Patient, anesthesiologist and surgeon are blinded
| Placebo | Drug | Infusion of NaCl (sodium chloride) 0.9% (placebo eq. 0.5ml/kg of NaCl 0.9%) |
|
PPI (pupillary pain index) by pupillometry with "AlgiScan®" monitoring, before endotracheal intubation and with a State Entropy of 50-60, then every 5 min between endotracheal intubation and surgical incision
| through study completion, an average of 3 months |
| PRD Measure | PRD (pupillary reflex dilatation) during laryngoscopy maintained for 30 sec, surgical incision and 10min after surgical incision | through study completion, an average of 3 months |