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Hemodynamic parameters and lactate level will be on CBP during CABG surgery patients.
Objective: To compare hemodynamic parameters of propofol and sevoflurane during cardiopulmonary bypass time in patients undergoing coronary artery bypass graft (CABG) surgery to avoid lactate level.
Methods: One hundred and twenty six patients scheduled for CABG from May 2017 to May 2018 will be included in this study. Non probability consecutive sampling will be used. Patients will be divided in two groups, propofol will be given to group 1, and sevoflurane will be given to group 2. Age, clamp time, bypass time, mean arterial blood pressure on bypass machine and lactate level will be compared between two groups. SPSS version 24 will used and p value ≤ 0.05 will be considered as significant.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group 1 Profol Infusion to CABG patients to check lactate level | Experimental | Propofol infusion according to bodyweight will be given to check lactate level on CPB |
|
| sevoflurane will be given to group 2 to check lacate level | Active Comparator | Sevoflurane MAC % will be given to CABG patients to check lactate level |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propofol | Drug | Propofol infusion according to body weight will be compared with sevoflurane acording to MAC % to see the lactate level and hemodynamic parameters of CABG patients |
| Measure | Description | Time Frame |
|---|---|---|
| Lactate level will be measured during CPB for CABG patients to see the hemodynamics parameters | The mean pre-cross clamp lactate level and post- rewarming lactate level will be calculated to see the effect of this on the CABG patients hemodynamics during CBP | 06 months |
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Inclusion Criteria:
CABG
Exclusion Criteria:
Emergency surgery
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kaneez Ume Farwa, FCPS | Contact | +923356787214 | farwatirmizi@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Kaneez Ume Farwa, FCPS | Chaudhry Pervaiz Elahi Institute of Cardiology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiac Surgery ICU | Recruiting | Multan | Punjab Province | 66100 | Pakistan |
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| ID | Term |
|---|---|
| D015742 | Propofol |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |