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| Name | Class |
|---|---|
| University Hospital Hradec Kralove | OTHER |
| Longevitytech.fund a.s. | UNKNOWN |
| Clock Foundation | UNKNOWN |
| AGECURVE LIMITED |
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The aim of the study is to evaluate the effect of plasmapheresis (repeated plasma withdrawals) on selected health indicators (hematological, biochemical, immunological and indicators of biological age) of plasma donors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Group 1 consists of first time donors undergoing all 8 tracked plasmaphereses. |
| |
| Group 2 | Group 2 consists of first time donors undergoing only last 4 plasmaphereses, serving as control for the first 4 donations. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Plasmapheresis | Procedure | Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor. |
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| Measure | Description | Time Frame |
|---|---|---|
| Significant change of biological age according to epigenetic clock after 8 plasmaphereses | Significant change of the epigenetic age of the plasma donors after 8 cycles of plasmapheresis conducted or a slower increase of the biological age throughout the study than the increase of the chronological age. | Through study completion, an average of 8 months |
| Measure | Description | Time Frame |
|---|---|---|
| Significant change of biological age according to epigenetic clock after 8 plasmaphereses | Significant change of the epigenetic age of the plasma donors after 4 cycles of plasmapheresis conducted or a slower increase of the biological age throughout the study than the increase of the chronological age. | Through study completion, an average of 8 months |
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Inclusion Criteria:
Exclusion Criteria:
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41 donors are welcomed to begin with the study. The participants are divided into 2 groups (Group 1 = therapeutic, Group 2 = half control) using stratified randomization, major criteria being chronological age and BMI, minor criteria being illness/medication, smoking, COVID in past 3 months, covid vaccination.
Group 1 consists of 28 participants (14 female, 14 male). Group 2 consists of 13 participants (7 female, 6 male). We suppose that the number of participants will decline during each phase of the study, approx. 10% before it even starts, 10% in the middle, 10% in the end. The goal is to have more than 30 participants finishing the study.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charles University, Medical Faculty in Hradec Kralove | Hradec Králové | Czechia |
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| ID | Term |
|---|---|
| D010956 | Plasmapheresis |
| ID | Term |
|---|---|
| D001781 | Blood Component Removal |
| D013812 | Therapeutics |
| D016060 | Sorption Detoxification |
| D005112 | Extracorporeal Circulation |
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| UNKNOWN |
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| Significant change of the proteomic profile after 8 plasmaphereses | Proteomic analysis showing signs of a rejuvenated proteostasis in the plasma donors after 8 cycles of plasmapheresis. | Through study completion, an average of 8 months |
| Significant change of the proteomic profile after 4 plasmaphereses | Proteomic analysis showing signs of a rejuvenated proteostasis in the plasma donors after 8 cycles of plasmapheresis. | Through study completion, an average of 8 months |
| Significant change of the biological age according to a blood biochemistry clock after 8 plasmaphereses | Blood biochemistry clock showing phenotype of a younger individual in the plasma donors after 8 cycles of plasmapheresis. | Through study completion, an average of 8 months |
| Significant change of the biological age according to a blood biochemistry clock after 4 plasmaphereses | Blood biochemistry clock showing phenotype of a younger individual in the plasma donors after 8 cycles of plasmapheresis. | Through study completion, an average of 8 months |
| D013514 | Surgical Procedures, Operative |