Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Brielle Orthopedics | UNKNOWN |
| University Orthopedics Associates | UNKNOWN |
Not provided
Not provided
Not provided
Not provided
Not provided
Steroids are often prescribed for their anti-inflammatory effects in patients with musculoskeletal injuries. Studies have shown that steroids may reduce pain and swelling, but their effects on range of motion and functional outcomes have not been illustrated. With this study, we aim to evaluate the effect of steroids on range of motion and functional outcomes in non-operatively managed musculoskeletal injuries of the hand.
Previous studies have investigated the effect of steroids on bone healing, edema reduction and postoperative pain. However, there seems to be a lack of literature on whether the use of steroids for their anti-inflammatory effects actually lead to improved range of motion and functional capacity. If the data shows that steroids do indeed help patients achieve increased functional outcomes, they may be used with higher confidence in their beneficial contribution to patient treatment and quality of life. If, however, the data show that steroids do not confer a significant benefit, they can be disregarded as they will avoid the risks associated with steroid use. We aim to investigate if the use of methylprednisolone will result in significantly improved ranges of motion and self-reported function compared to a control group at each measurement time point.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Steroid Group | Experimental | Patients receive 21 tablets of 4 mg methylprednisolone to be taken by mouth over a 6 week taper. Patients will be advised to not take other anti-inflammatory medications like NSAIDs. |
|
| Control Group | Active Comparator | Patients will recieve standard treatment that focuses on mobilization and stabilization using common techniques like buddy taping and splinting. Pain control will be managed using non-NSAID medications like Tylenol or opioid narcotics when deemed medically necessary. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Methylprednisolone Tablet | Drug | Subjects will take a quantity 21 4mg tablets over a 6 week taper. |
|
| Measure | Description | Time Frame |
|---|---|---|
| wrist flexion | degrees of wrist flexion | initial |
| wrist flexion | degrees of wrist flexion | 3 weeks |
| wrist flexion | degrees of wrist flexion | 6 weeks |
| wrist flexion | degrees of wrist flexion | 12 weeks |
| wrist extension | degrees of wrist extension | 12 weeks |
| wrist extension | degrees of wrist extension | 6 weeks |
| wrist extension | degrees of wrist extension | 3 weeks |
| wrist extension | degrees of wrist extension | initial |
| hand supination | degrees of hand supination | initial |
| hand supination |
| Measure | Description | Time Frame |
|---|---|---|
| VAS Pain Scale | visual analog pain scale | 3 weeks |
| VAS Pain Scale | visual analog pain scale | 6 weeks |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bobby Varghese, MD | Contact | 8324657112 | bv209@rwjms.rutgers.edu | |
| Anna Green, MD | Contact | annagreen7@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Brian Katt, MD | Rutgers, The State University of New Jersey | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brielle Orthopedics | Brick | New Jersey | 08724 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25564196 | Background | Rytter S, Stilling M, Munk S, Hansen TB. Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2017 Jan;25(1):284-290. doi: 10.1007/s00167-014-3501-8. Epub 2015 Jan 7. | |
| 29747624 | Background | Yang Z, Lim PPH, Teo SH, Chen H, Qiu H, Pua YH. Association of wrist and forearm range of motion measures with self-reported functional scores amongst patients with distal radius fractures: a longitudinal study. BMC Musculoskelet Disord. 2018 May 11;19(1):142. doi: 10.1186/s12891-018-2065-z. |
| Label | URL |
|---|---|
| Rutgers REDCap server that stores study data | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D006230 | Hand Injuries |
| D005383 | Finger Injuries |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
Not provided
Not provided
| ID | Term |
|---|---|
| D008775 | Methylprednisolone |
| D000082 | Acetaminophen |
| D009294 | Narcotics |
| ID | Term |
|---|---|
| D011239 | Prednisolone |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
Not provided
Not provided
Not provided
Not provided
Not provided
data without intervention identification will be analyzed by outcome assessor
| Standard Mobilization Treatment | Other | standard treatment of hand injuries with focus on mobilization. No anti-inflammatory medications. Pain management via Tylenol or narcotics if deemed necessary. |
|
|
degrees of hand supination |
| 3 weeks |
| hand supination | degrees of hand supination | 6 weeks |
| hand supination | degrees of hand supination | 12 weeks |
| hand pronation | degrees of hand pronation | initial |
| hand pronation | degrees of hand pronation | 3 weeks |
| hand pronation | degrees of hand pronation | 6 weeks |
| hand pronation | degrees of hand pronation | 12 weeks |
| wrist ulnar deviation | degrees of wrist ulnar deviance | initial |
| wrist ulnar deviation | degrees of wrist ulnar deviance | 3 weeks |
| wrist ulnar deviation | degrees of wrist ulnar deviance | 6 weeks |
| wrist ulnar deviation | degrees of wrist ulnar deviance | 12 weeks |
| wrist radial deviation | degrees of radial deviance of the wrist | initial |
| wrist radial deviation | degrees of radial deviance of the wrist | 3 weeks |
| wrist radial deviation | degrees of radial deviance of the wrist | 6 weeks |
| wrist radial deviation | degrees of radial deviance of the wrist | 12 weeks |
| MCP, DIP, PIP of digits 2-5: Flexion | degrees of flexion for MCP, DIP, and PIP of digits 2-5 | initial |
| MCP, DIP, PIP of digits 2-5: Flexion | degrees of flexion for MCP, DIP, and PIP of digits 2-5 | 3 weeks |
| MCP, DIP, PIP of digits 2-5: Flexion | degrees of flexion for MCP, DIP, and PIP of digits 2-5 | 6 weeks |
| MCP, DIP, PIP of digits 2-5: Flexion | degrees of flexion for MCP, DIP, and PIP of digits 2-5 | 12 weeks |
| MCP, DIP, PIP of digits 2-5: Extension | degrees of extension for MCP, DIP, and PIP of digits 2-5 | initial |
| MCP, DIP, PIP of digits 2-5: Extension | degrees of extension for MCP, DIP, and PIP of digits 2-5 | 3 weeks |
| MCP, DIP, PIP of digits 2-5: Extension | degrees of extension for MCP, DIP, and PIP of digits 2-5 | 6 weeks |
| MCP, DIP, PIP of digits 2-5: Extension | degrees of extension for MCP, DIP, and PIP of digits 2-5 | 12 weeks |
| MCP, DIP, PIP of digits 2-5: abduction | degrees of abduction for MCP, DIP, and PIP of digits 2-5 | initial |
| MCP, DIP, PIP of digits 2-5: abduction | degrees of abduction for MCP, DIP, and PIP of digits 2-5 | 3 weeks |
| MCP, DIP, PIP of digits 2-5: abduction | degrees of abduction for MCP, DIP, and PIP of digits 2-5 | 6 weeks |
| MCP, DIP, PIP of digits 2-5: abduction | degrees of abduction for MCP, DIP, and PIP of digits 2-5 | 12 weeks |
| MCP, DIP, PIP of digits 2-5: adduction | degrees of adduction for MCP, DIP, and PIP of digits 2-5 | initial |
| MCP, DIP, PIP of digits 2-5: adduction | degrees of adduction for MCP, DIP, and PIP of digits 2-5 | 3 weeks |
| MCP, DIP, PIP of digits 2-5: adduction | degrees of adduction for MCP, DIP, and PIP of digits 2-5 | 6 weeks |
| MCP, DIP, PIP of digits 2-5: adduction | degrees of adduction for MCP, DIP, and PIP of digits 2-5 | 12 weeks |
| Thumb Opposition at MCP | degrees of thumb opposition | initial |
| Thumb Opposition at MCP | degrees of thumb opposition | 3 weeks |
| Thumb Opposition at MCP | degrees of thumb opposition | 6 weeks |
| Thumb Opposition at MCP | degrees of thumb opposition | 12 weeks |
| Thumb extension at IP | degrees of thumb IP extension | initial |
| Thumb extension at IP | degrees of thumb IP extension | 3 weeks |
| Thumb extension at IP | degrees of thumb IP extension | 6 weeks |
| Thumb extension at IP | degrees of thumb IP extension | 12 weeks |
| Thumb flexion at IP | degrees of thumb IP flexion | initial |
| Thumb flexion at IP | degrees of thumb IP flexion | 3 weeks |
| Thumb flexion at IP | degrees of thumb IP flexion | 6 weeks |
| Thumb flexion at IP | degrees of thumb IP flexion | 12 weeks |
| Quick DASH Questionnaire | patient-reported outcome survey that evaluates functionality and patient-perceived disability | 6 weeks |
| Quick DASH Questionnaire | patient-reported outcome survey that evaluates functionality and patient-perceived disability | 12 weeks |
| VAS Pain Scale | visual analog pain scale | 12 weeks |
| Complications | list of adverse events | 3 weeks |
| Complications | list of adverse events | 6 weeks |
| Complications | list of adverse events | 12 weeks |
| Edema Measurements | measurements of noted edema to the study area | 3 weeks |
| Edema Measurements | measurements of noted edema to the study area | 6 weeks |
| Edema Measurements | measurements of noted edema to the study area | 12 weeks |
| University Orthopedics Associates | Somerset | New Jersey | 08873 | United States |
| 2395047 | Background | Troullos ES, Hargreaves KM, Butler DP, Dionne RA. Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus. J Oral Maxillofac Surg. 1990 Sep;48(9):945-52. doi: 10.1016/0278-2391(90)90007-o. |
| 19240368 | Background | Boursinos LA, Karachalios T, Poultsides L, Malizos KN. Do steroids, conventional non-steroidal anti-inflammatory drugs and selective Cox-2 inhibitors adversely affect fracture healing? J Musculoskelet Neuronal Interact. 2009 Jan-Mar;9(1):44-52. |
| D013256 |
| Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
| D002492 | Central Nervous System Depressants |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D000700 | Analgesics |
| D018689 | Sensory System Agents |
| D018373 | Peripheral Nervous System Agents |
| D002491 | Central Nervous System Agents |
| D045506 | Therapeutic Uses |