This study will be evaluated safety of undenatured collagen type II (UCII) supplement in 60 healthy volunteer. Liver function test, renal function test, and adverse event will be assessed.

This study will be evaluated safety of undenatured collagen type II (UCII) supplement in 60 healthy volunteer. The undenatured collagen type II (UCII) supplement 40 mg will be taken once daily for 2 months. Liver function test, renal function test, and adverse event will be assessed before and after taking for 1 and 2 months.

Inclusion Criteria:

• Age 20-60 years
• No taking collagen supplement more than 2 weeks
• No collagen and protein allergy
• No liver and renal disease
• Have a willingness to participate in the study

Exclusion Criteria:

• Uncontrolled disease
• Have complication symptom during study
• Pregnancy or lactation
• Cannot follow the protocol
• During participated in other studies