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| Name | Class |
|---|---|
| The Second Hospital of Shandong University | OTHER |
| Chaoyang Central Hospital | OTHER |
| The General Hospital of Fushun Mining Bureau | UNKNOWN |
| The fourth People's Hospital of Changzhou |
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To assist postoperative pathological diagnosis and classification of gastric cancer by machine learning; To improve the accuracy of pathological diagnosis of gastric cancer by machine learning; To predict the effectiveness of treatment for gastric cancer by deep learning; To construct a model to predict the survival of gastric cancer patients by multimodal deep learning.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Training Group | Based on the inclusion criteria, 2000 gastric cancer patients will be recruited in the analysis. And a model will be constructed based on deep learning. |
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| Internal Validation Group | Based on the inclusion criteria, 1000 gastric cancer patients will be recruited in this group to verify the sensitivity and specificity of the constructed model. |
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| External Validation Group | Based on the inclusion criteria, 300 gastric cancer patients from 5 other medical centers will be recruited in this group to verify the sensitivity and specificity of the constructed model. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The whole abdomen contrast-enhanced CT scan | Radiation | All the participants were measured by the whole abdomen contrast-enhanced CT scan. |
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| Measure | Description | Time Frame |
|---|---|---|
| Maximum diameter of tumor | To measure the maximum diameter of tumor on preoperative enhanced abdominal CT of patients with gastric cancer. | 1 day |
| Growth pattern | To assess the growth pattern on preoperative enhanced abdominal CT of patients with gastric cancer, including endophytic, exophytic and mixed. | 1 day |
| Enhancement pattern | To assess the enhancement pattern on preoperative enhanced abdominal CT of patients with gastric cancer, including homogeneous and heterogeneous. | 1 day |
| Enhancement degree | To assess the enhancement degree on preoperative enhanced abdominal CT of patients with gastric cancer, including hypoenhancement, isoenhancement and hyperenhancement. | 1 day |
| Nucleus size | To obtain the nucleus size of postoperative H&E stained sections and slides of gastric cancer by deep learning. | 1 day |
| Nucleus shape | To obtain the nucleus shape of postoperative H&E stained sections and slides of gastric cancer by deep learning. | 1 day |
| Distribution of pixel intensity | To obtain the distribution of pixel intensity of postoperative H&E stained sections and slides of gastric cancer by deep learning. | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Survival status | To analyze the survival status of patients with gastric cancer, involving dead and alive. | 1 day |
| Overall survival | To calculate the overall survival of patients with gastric cancer based on days to death and days to last follow-up. |
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Inclusion Criteria:
Exclusion Criteria:
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3000 gastric cancer patients will participate in the phase I study, they will be divided into training group and internal validation group. 300 gastric cancer patients in five other medical centers will form the external validation group.
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| Name | Affiliation | Role |
|---|---|---|
| Kai Li, MD | First Hospital of China Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The fourth People's Hospital of Changzhou | Changzhou | Jiangsu | 213001 | China | ||
| Chaoyang Central Hospital |
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| ID | Term |
|---|---|
| D013274 | Stomach Neoplasms |
| D004194 | Disease |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| UNKNOWN |
| First Hospital of Jinzhou Medical University | UNKNOWN |
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| H&E stained sections and slides | Other | HE pathological examination was performed on all specimens of enrolled patients. |
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| Texture of nuclei | To obtain the texture of nuclei of postoperative H&E stained sections and slides of gastric cancer by deep learning. | 1 day |
| 1 day |
| Recurrence/metastasis | To calculate the days to recurrence/metastasis of patients with gastric cancer. | 1 day |
| Chaoyang |
| Liaoning |
| 122099 |
| China |
| The General Hospital of Fushun Mining Bureau | Fushun | Liaoning | 113012 | China |
| First Hospital of Jinzhou Medical University | Jinzhou | Liaoning | 121012 | China |
| The First Affiliated Hospital of China Medical University | Shenyang | Liaoning | 110000 | China |
| The Second Hospital of Shandong University | Ji'nan | Shandong | 250033 | China |
| D004066 |
| Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |