Purpose: To investigate the short-term clinical effect of curcumin-containing toothpaste on halitosis as compared to placebo and to assess potential shifts in the composition of dental biofilm associated with the use of curcumin-containing toothpaste

Participants: This clinical study will 30 adult participants under prophylactic or periodontal maintenance protocol.

Procedures (methods): Participants will be included and throughout the protocol will not allow the use any other oral hygiene products except standard manual toothbrush and study toothpaste (either test -curcumin-containing or placebo). Additionally participants will be instructed to odiferous foods such as onions, garlic and spices. At each of the three examination sessions, Plaque Index (six sites, O'Leary) and volatile sulphur compounds (VSC) will be measured.

Inclusion Criteria

• Participants must be adult males or females between the ages of 18 and 65 years (inclusive) reporting halitosis
• Participants must be able and willing to follow study procedures and instructions
• Participants must have read, understood and signed an informed consent form
• Participants must present with at least 8 teeth in the functional dentition and with at least 4 teeth in each posterior sextant, 3 of which are adjacent teeth with interproximal papilla in each posterior sextant that will have the stent
• Participants must be in good general health

Exclusion Criteria

• Patients ongoing restorative or periodontal dental treatment or any other medical treatment
• Subjects with any pathological alterations of the oral mucosa
• Any known allergy to previously used oral hygiene products or any known allergy to any of the ingredients of the study products, which are used during the study
• Pregnant women
• Subjects with untreated periodontitis or active caries lesion
• Subjects diagnosed with acute sinusitis, bronchitis or tonsillitis
• Subjects under treatment on medications which can cause malodor, e.g. amphetamines, nitrates and nitrites
• Known diabetes, liver or kidney insufficiency
• Subjects diagnosed with reduced salivary flow due to pathological reasons (e.g. Sjögren syndrome)
• Subjects who underwent preventive periodontal treatment, i.e. oral prophylaxis treatment, within the last week
• Volunteers unwilling to abstain from additional oral hygiene (only tooth brushing allowed) particularly mouthrinse, chewing gums, breath strips, etc and alcohol 12 h prior the first measurement at the study site and until the completion of all measurements

Deidentified individual data that supports the results will be shared beginning 9 to 36 months following publication provided the investigator who proposes to use the data has approval from an Institutional Review Board (IRB), Independent Ethics Committee (IEC), or Research Ethics Board (REB), as applicable, and executes a data use/sharing agreement with UNC.

9 to 36 months following publication

The investigator who proposes to use the data has approval from an IRB, IEC, or REB and an executed data use/sharing agreement with UNC.