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The project is planed to explore the impact of LTBP4 and other matrix protein and potentially related biomarkers on renal outcomes, cardiac outcomes and all-cause mortality in patients with suspected acute coronary syndrome (ACS).
The investigators will collect the blood samples from patients with suspect ACS. LTBP4 will be the first matrix protein that are going to understand. Upon hospital arrival, blood samples around 8 ml will be collected and the 2nd collection will be two weeks to one month after the event. The third collection will be one year later. In the between, if any ACS event develop, blood samples will be collected as protocols.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| suspect acute coronary syndrome | Subjects with the diagnosis of suspected acute coronary syndrome (ACS), age between 20 to 80. Exclusion criteria: pregnant women, patients with end-stage renal disease (eGFR <15 mL/min/1.73 m2), cardiogenic shock. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change of renal functions | The investigators will follow up Cr and eGFR levels correlate with LTBP4 levels | One month, Six month and one year |
| All cause mortality | 3 years | |
| Incidence of hospitalization | 3 years | |
| Incidence of required myocardial revascularization | 3 years |
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Inclusion Criteria:
- acute coronary syndrome patients
Exclusion Criteria:
- cardiogenic shock, pregnancy, end-stage renal disease
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Subjects between 20-80 yrs, with acute coronary syndrome in NTUH.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chi-Ting Su, MD. MPH, PhD | Contact | +886972652878 | A01218@ntucc.gov.tw | |
| Yue-Jhu Huang, MS | Contact | +886912282113 | yuejhuhuang@outlook.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University Hospital | Recruiting | Taipei | Taiwan |
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| ID | Term |
|---|---|
| D054058 | Acute Coronary Syndrome |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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