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| Name | Class |
|---|---|
| Westlake University | OTHER |
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The research is designed to study the prognostic factors of ventriculoperitoneal (VP) shunt for iNPH by multi-omics research
Preoperative T1-MRI, functional MRI and diffusion MRI imaging data of iNPH patients were collected. The clinical assessment was performed before/after the lumbar puncture test and 6 months after VP shunt. Clinical assessment included Mini-mental State Examination (MMSE), gait scores, Kiefer score, and Modified Rankin Scale (mRS). The cerebrospinal fluid was collected by tap-test, and 6 months after surgery by puncturing in the VP device pump.
Methods- The primary methods used are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| iNPH cohort | Experimental | The patients diagnosed of iNPH. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ventriculo-peritoneal shunt | Procedure | A ventriculoperitoneal shunt is a tube that drains excess cerebrospinal fluid into abdomen |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proteomic pattern of CSF in iNPH patients | Comparing the proteomic pattern differences in CSF between iNPH patients and normal age-matched normal volunteers by the analysis of mass spectrometry. Also, the responsive and non-responsive iNPH patients proteomic pattern were analzed. | Before surgery in lumbar CSF |
| Proteomic pattern changes of CSF in iNPH patients after VP shunt | Comparing the proteomic pattern differences in CSF of iNPH patients before surgery and after VP shunt by the analysis of mass spectrometry. Also, the responsive and non-responsive iNPH patients proteomic pattern were analzed. | Change from Baseline (ventricular CSF) at 6 months after VP shunt |
| Measure | Description | Time Frame |
|---|---|---|
| Gray Matter Density | Using automatic cortical and subcortical segmentation from the 3-dimensional T1weighted images to measure gray matter density in iNPH patients before surgery compared with healthy individual group. Also, the responsive and non-responsive iNPH patients structral MRI were analzed. | Before surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Junming Zhu, M.D. | Contact | 86-13968055768 | dr.zhujunming@zju.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Zhoule Zhu | Second Affiliated Hospital, School of Medicine, Zhejiang University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The second affliated hospital of zhejiang university | Recruiting | Hangzhou | Zhejiang | 310009 | China |
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| ID | Term |
|---|---|
| D017287 | Ventriculoperitoneal Shunt |
| ID | Term |
|---|---|
| D002557 | Cerebrospinal Fluid Shunts |
| D000714 | Anastomosis, Surgical |
| D013514 | Surgical Procedures, Operative |
| D019635 | Neurosurgical Procedures |
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| Change in the resting state fMRI |
Change of BOLD singal intensity in the resting state fMRI in iNPH patients compared with normal healthy group. Also, the responsive and non-responsive iNPH patients functional MRI were analzed. |
| Before surgery |
| White matter abnormity | Franctional anisotropy, mean diffusivity and apparent diffusion coefficient were measured by diffusion MRI in region of interest of iNPH patients compared with normal healthy group. Also, the responsive and non-responsive iNPH patients diffusion MRI were analzed. | Beore surgery |
| Kiefer score | A score for iNPH severity; range 0-26; higher indicates higher severity. | Change from Baseline at 6 months after VP shunt |
| Mini mental state Examination | A score for cognitive ability; range 0-30; higher indicates higher severity. | Change from Baseline at 6 months after VP shunt |
| Gait evaluation | 10 meters walking test were evaluated of iNPH patients. | Change from Baseline at 6 months after VP shunt |
| modified Rankin scale | A score for functional neurological status ; range 0-5; higher indicates higher severity. | Change from Baseline at 6 months after VP shunt |