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Hip fracture pain is often severe and traditionally managed by systemic opioids which have increased risk of side effects in frail elderly patients. Inadequately controlled pain may lead to delirium which increases mortality and morbidity. The overall aim of this RCT is to investigate the potential for improved pain relief accomplished by the addition of the PENG block to current standard practice of pre-operative analgesia (systemic morphine), compared to the control group, which involves no block (operator will still go through the motion as if performing a block) plus standard pre-operative analgesia.
The investigator hypothesize that the addition of a single shot PENG block at the side of hip fracture in addition to traditional systemic morphine provides good preoperative pain relief on movement and reduces the need for breakthrough opioid requirements. The investigator hypothesize that the interventional group dynamic pain score assessed at 30 minutes after the block compared to control group dynamic pain score at 30 minutes after the "block" will be at least a 3 point difference between the 2 groups .
Specific Aim1: To determine difference in pain scores on movement (dynamic pain scores) in patients who receive the PENG block in the intervention group compared to no block in the control group at 30 minutes after performance of the block.
Specific Aim2: To determine if there is any difference in pain at rest between the intervention group and the control group, and if so, the magnitude of the difference in pain scores.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | Only standard care |
|
| Intervention group | Experimental | The PENG block was performed for intervention group with local anaesthetic solution composed of 20 ml of ropivacaine 0.5%. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ropivacaine 0.5% Injectable Solution | Drug | Local anaesthetic solution composed of ropivacaine 0.5%(intervention group) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Dynamic pain scores (Numerical pain score (NRS) at 15 degrees leg lift) | The difference in dynamic pain scores (NRS at 15 degrees leg lift) at 30 minutes post block performance in the intervention group vs the control group. Assessment of the dynamic pain score is done prior to discharge from recovery at SGH Pain Management Centre. | 30 minutes after receiving intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Pain scores (NRS) at rest (static pain) and on movement (dynamic pain) | It is measured at Baseline, Immediately after performance of block, 30 minutes after the lock in recovery At 60 minutes, 180 minutes and 24 hours post block in the ward | Up to 24 hours from performance of block |
| Pain scores collected to estimate the onset and duration of block Pain scores to estimate the onset and duration of block |
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Inclusion Criteria:
Exclusion Criteria:
Patients with cognitive impairment or inability to give consent, or refusal to give consent
Multiple fracture cases
Peri-prosthetic fractures and revisions
Subclinical vertebral fractures
Hip fractures due to major accidents such as road traffic accidents, fall from height or more than 2 meters
Multiple trauma
Pathological fractures secondary to metastases
Patients with contraindications to block performance
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pain Management Center Sinagpore General Hospital | Recruiting | Singapore | 169608 | Singapore |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27075376 | Result | Tay E. Hip fractures in the elderly: operative versus nonoperative management. Singapore Med J. 2016 Apr;57(4):178-81. doi: 10.11622/smedj.2016071. | |
| 30063657 | Result | Giron-Arango L, Peng PWH, Chin KJ, Brull R, Perlas A. Pericapsular Nerve Group (PENG) Block for Hip Fracture. Reg Anesth Pain Med. 2018 Nov;43(8):859-863. doi: 10.1097/AAP.0000000000000847. |
| Label | URL |
|---|---|
| Anaesthetic management of patients with hip fractures: an update | View source |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Mar 12, 2023 | |
| Reset | Dec 13, 2023 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Mar 12, 2023 | Dec 13, 2023 |
| ID | Term |
|---|---|
| D006620 | Hip Fractures |
| D010146 | Pain |
| ID | Term |
|---|---|
| D005264 | Femoral Fractures |
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
| D025981 | Hip Injuries |
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| ID | Term |
|---|---|
| D000077212 | Ropivacaine |
| D059039 | Standard of Care |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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Patient, nurses and CRC will be blinded. Rest of study team is not blinded.
| Placebo | Drug | Standard care |
|
|
Taking the recorded time taken for the pain relieve to estimate onset time using models |
| Up to 24 hours from performance of block |
| Total opioid use over 24 hours as a surrogate measure | Using the data recorded for : Oral morphine use Intravenous morphine use for patients on PCA Doses of opioid use will be converted to morphine milligram equivalent daily dose (MEDD) for standardized comparison. | Up to 24 hours from performance of block |
| 37055189 | Derived | Lin X, Liu CW, Goh QY, Sim EY, Chan SKT, Lim ZW, Chan DXH. Pericapsular nerve group (PENG) block for early pain management of elderly patients with hip fracture: a single-center double-blind randomized controlled trial. Reg Anesth Pain Med. 2023 Nov;48(11):535-539. doi: 10.1136/rapm-2022-104117. Epub 2023 Apr 13. |
| D007869 |
| Leg Injuries |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000588 |
| Amines |
| D019984 | Quality Indicators, Health Care |
| D011787 | Quality of Health Care |
| D006298 | Health Services Administration |
| D017530 | Health Care Quality, Access, and Evaluation |