Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
CT scans of the chest / thorax are of great importance both in the initial diagnosis and in the follow-up of pulmonary or thoracic diseases. As an example, CT angiography of the pulmonary arteries (CTPA) is worldwide considered to be gold standard test in patients with a suspicion for pulmonary embolism.
The aim of this study is to measure and compare dose efficiency of modern CT scanners for unenhanced and contrast-enhanced scan protocols of the chest/thorax. Patients who are referred for a CT of the chest/thorax will be randomly assigned to one of the three CT scanners currently in use at our institution.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Scanner 1 | Other | Imaging performed on scanner 1: Photon-Counting Detector CT |
|
| Scanner 2 | Other | Imaging performed on scanner 2: Energy-Integrating Detector CT (128-slice) |
|
| Scanner 3 | Other | Imaging performed on scanner 3: Energy-Integrating Detector CT (20-slice) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Imaging on Scanner with Spectral Imaging Capabilities | Diagnostic Test | Patients will undergo imaging on a modern CT scanner with spectral imaging capabilities. A dose neutral spectral acquisition mode will routinely be used. Contrast material protocol and scan ranges are similar in all three arms. |
| Measure | Description | Time Frame |
|---|---|---|
| Parameters of Objective Image Quality | Measured as signal, image noise and modulation transfer function equivalent parameters | 1 year |
| Parameters of Radiation Dose | measured as x-ray tube parameters such as dose length product (DLP) | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective Image Quality Evaluation (entire cohort and for individual disease groups) | measured by blinded evaluation by radiologists | 1 year |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Florian Schwarz, MD | Universitaetsklinikum Augsburg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Augsburg | Augsburg | Bavaria | 86156 | Germany |
We plan to share individual participant data upon request (pending final approval by the data protection officer).
Requests for sharing individual participant data will be considered at the time of publication of the first manuscript containing result data.
We plan to share data on request at this point in time.
Not provided
Not provided
Randomization of patients referred for a CT scan of the thorax on one of three CT scanners routinely used for this purpose in our department
Not provided
Not provided
no masking required
Not provided
|
|
| CT Scan using an Energy-Integrating Detector CT (128 slice MDCT) | Diagnostic Test | Patients will undergo imaging on a modern 128-slice CT scanner (Siemens Healthineers) with energy-integrating detector and without spectral acquisition mode. Contrast material protocol and scan ranges are similar in all three arms. |
|
| CT Scan using an Energy-Integrating Detector CT (20-slice MDCT) | Diagnostic Test | Patients will undergo imaging on a modern 20-slice CT scanner (Siemens Healthineers) with energy-integrating detector and without spectral acquisition mode. Contrast material protocol and scan ranges are similar in all three arms. |
|
| ID | Term |
|---|---|
| D011014 | Pneumonia |
| D008175 | Lung Neoplasms |
| D011655 | Pulmonary Embolism |
| D008171 | Lung Diseases |
| D001024 | Aortic Valve Stenosis |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D012140 | Respiratory Tract Diseases |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004617 | Embolism |
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D014694 | Ventricular Outflow Obstruction |
Not provided
Not provided