Analysis of the Molecular Profile of the Mixofibrosarcoma of the Extremities

Analysis of the Molecular Profile of the Mixofibrosarcoma of the Extremities: Diagnostic and Prognostic Impact

Single institution case series review with a histological diagnosis of mixofibrosarcoma of the extremities from 01 Jan 1993 to 01 Dec 2017.

The study will exam all the clinical, radiological, histological and immunohistochemical features of this tumour in all samples and in a limited serie of cases the presence of mutation of 50 genes cancer related.

Inclusion Criteria:

1. Male and female patients treated at Rizzoli Institute from 01 Jan 1993 to 01 Dec 2017
2. Diagnosis of mixofibrosarcoma of extremities
3. Histological slides/formalin-fixed paraffin-embedded tissue tumor (FFPE) blocks from archive available to perform the histology analysis and molecular analysis
4. Enough tumor biobanked material available for molecular analysis
5. Presence of the biobank signed informed consent
6. Written informed consent prior to any study-specific analysis and/or data collection

Exclusion Criteria:

1) Patients with histological diagnosis different from mixofibrosarcoma of extremities