The objective of this study is to assess the effects of replacing energy from SoFAS with energy from avocado on non-high-density lipoprotein cholesterol (non-HDL-C) and other aspects of the cardiometabolic health profile including fasting lipoprotein lipid and particle concentrations, insulin sensitivity and blood pressure in men and women with elevated triglycerides (TG).

Inclusion Criteria:

1. Male or female 21 to 74 y of age, inclusive.
2. Subject has a fasting fingerstick TG level of ≥135 mg/dL and <500 mg/dL at screening.
3. Subject has a BMI of 25.00 to 39.99 kg/m2, inclusive.
4. Subject has a vein access score of 7-10.
5. Subject is normally active and judged by the Investigator to be in general good health on the basis of medical history and screening measurements.
6. Subject is willing to comply with study food and background diet consumption during each treatment condition.
7. Subject is willing follow his/her regular physical activity pattern throughout the study period.
8. Subject is willing to refrain from consumption of all forms of recreational and/or medicinal marijuana (if legal) and alcoholic beverages for 24 h prior to each clinic visit requiring a blood draw.
9. Subject is willing to refrain from vigorous physical activity for 24 h prior to each clinic visit requiring a blood draw.
10. Subject is willing to abstain from caffeine use 1 h prior to and during each clinic visit
11. Subject is a non-smoker (at least 6 months), does not vape, and does not use other nicotine products and will abstain from use during the study period.
12. Subject who uses cannabidiol (CBD) and/or tetrahydrocannabinol (THC) has no plans to change habits during the study period.
13. Subject understands the study procedures and signs forms documenting informed consent to participate in the study and authorization for release of relevant protected health information to the study Investigator and is willing to complete study procedures.

Exclusion Criteria:

1. Subject has a laboratory test result of clinical significance based on the judgment of the Principal Investigator or qualified designee.
2. Subject has positive urine drug screen for illicit drugs.
3. Subject has fasting blood glucose ≥126 mg/dL at screening or known type 1 or type 2 diabetes mellitus.
4. Subject has atherosclerotic cardiovascular disease including any of the following: clinical signs of atherosclerosis including peripheral arterial disease, abdominal aortic aneurysm, carotid artery disease (symptomatic [e.g., myocardial infarction, angina, transient ischemic attack or stroke of carotid origin] or >50% stenosis on angiography or ultrasound) or other forms of clinical atherosclerotic disease (e.g., renal artery disease).
5. Subject has history or presence of a clinically significant gastrointestinal, endocrine, renal, hepatic, hematologic, immunologic, dermatologic, pulmonary, pancreatic, neurologic, psychiatric, inflammatory or biliary disorder that, in the opinion of the Investigator, could interfere with the interpretation of the study results.
6. Subject has a history of cancer in the prior 2 years, with the exception of non- melanoma skin cancer or carcinoma in situ of the cervix.
7. Subject has uncontrolled hypertension (systolic blood pressure ≥160 mm Hg and/or diastolic blood pressure ≥100 mm Hg) at screening.
8. Subject has unstable use (defined as initiation or change in dose) of anti-hypertensive medication or thyroid hormone replacement within 4 weeks of screening.
9. Subject has used beta-adrenergic blockers and/or high-dose (>25 mg/d) thiazide diuretics within 4 weeks of screening.
10. Subject has unstable use (defined as initiation or change in dose, agent, or regimen) of statins within 4 weeks of screening.
11. Subject has used lipid-altering drugs other than statins including, but not limited to, bile acid sequestrants, cholesterol absorption inhibitors or fibrates within 4 weeks of screening.
12. Subject has used diabetes medications including alpha-glucosidase inhibitors, biguanides and biguanide combinations, thiazolidinediones, dipeptidyl peptidase-4 inhibitors, meglitinides and sulfonylureas and combination sulfonylureas within 4 weeks of screening.
13. Subject has used systemic corticosteroids within 4 weeks of screening.
14. Subject has used weight-loss drugs (including over-the-counter medications and/or supplements) or programs within 4 weeks prior to screening.
15. Subject has used lipid-altering foods, herbs or dietary supplements, including omega-3 fatty acid supplements with ≥900 mg/d EPA (eicosapentaenoic acid) or DHA (docosahexaenoic acid), niacin or its analogs at doses >200 mg/d, sterol/stanol products, dietary fiber supplements or red rice yeast supplements within 2 weeks of screening.
16. Subject has used dietary supplements that may affect carbohydrate metabolism, including chromium picolinate, ginseng, cinnamon (as a supplement) and starch blockers within 2 weeks of screening.
17. Subject has had a weight change of ±4.5 kg (10 lbs) in the previous 3 months.
18. Subject has an active infection and/or is on antibiotic therapy. Subject can be rescheduled for screening 7 days after completion of antibiotic therapy.
19. Subject has extreme dietary habits (e.g., vegan or very low carbohydrate diet).
20. Subject has a history of a diagnosed eating disorder (e.g., anorexia or bulimia nervosa).
21. Subject is a female who is pregnant, planning to be pregnant during the study period, lactating, or is of childbearing potential and is unwilling to commit to the use of a medically approved form of contraception throughout the study period.
22. Subject has a known allergy, sensitivity or intolerance to any foods.
23. Subject has been exposed to any non-registered drug product within 30 days of screening.
24. Subject has a current or recent history (past 12 months of screening) or strong potential for illicit drug or alcohol abuse. Alcohol abuse will be defined as >14 drinks per week (1 drink = 12 oz beer, 5 oz wine, or 1.5 oz hard liquor).
25. Subject has a condition the Investigator believes would interfere with his or her ability to provide informed consent or comply with the study protocol, or which might confound the interpretation of the study results or put the person at undue risk.