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The purpose of this prospective randomized clinical trial is to compare the clinical outcomes between aspirin with ticagrelor versus aspirin with clopidogrel in high ischemic risk patients beyond 12 months after percutaneous coronary intervention with drug-eluting stent implantation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ticagrelor-based dual-antiplatelet therapy | Experimental | Aspirin with ticagrelor |
|
| Clopidogrel-based dual-antiplatelet therapy | Active Comparator | Aspirin with clopidogrel |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ticagrelor-based dual-antiplatelet therapy | Drug | Aspirin with ticagrelor |
|
| Measure | Description | Time Frame |
|---|---|---|
| Composite of all-cause death, myocardial infarction, or stroke | Composite of all-cause death, myocardial infarction, or stroke at 24 months after randomization | up to 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| BARC type 2, 3, or 5 bleeding | BARC type 2, 3, or 5 bleeding at 24 months after randomization | up to 24 months |
| All-cause death | All-cause death at 24 months after randomization |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Byeong-Keuk Kim | Contact | 82-2-2228-8460 | kimbk@yuhs.ac |
| Name | Affiliation | Role |
|---|---|---|
| Byeong-Keuk Kim | Yonsei University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Severance Hospital, Yonsei University Health System | Seoul | South Korea |
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Ticagrelor-based dual-antiplatelet therapy vs. Clopidogrel-based dual-antiplatelet therapy
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| Clopidogrel-based dual-antiplatelet therapy | Drug | Aspirin with clopidogrel |
|
| up to 24 months |
| Myocardial infarction | Myocardial infarction at 24 months after randomization | up to 24 months |
| Stroke | Stroke at 24 months after randomization | up to 24 months |
| Cardiac death | Cardiac death at 24 months after randomization | up to 24 months |
| Composite of all-cause death, myocardial infarction, stroke, or BARC type 2, 3, or 5 bleeding | Composite of all-cause death, myocardial infarction, stroke, or BARC type 2, 3, or 5 bleeding at 24 months after randomization | up to 24 months |