Cranberries are traditionally used for urinary comfort and prevention of urinary disorders of bacterial origin and despite an EFSA opinion invalidating the clinical efficacy of cranberries, its mechanism of action has been several times proposed by the scientific community: it would act by inhibiting the synthesis of P-fimbriae leading to a complete disappearance of these adhesins, and to bacterial-type deformation by lengthening of the cell body. Cinnamon and microbiotic strains could enhance this synergy.

This study aims to evaluate the effectiveness of a food supplement based on cranberry, cinnamon and microbiotic strains (Feminabiane CBU) on the symptoms of cystitis, urinary discomfort and the number of cystitis reported by women.

Women who use or not the cranberry, cinnamon, and microbiotic blend are encouraged to complete a 6-month diary in which they report any urinary tract disorders they encounter.

Inclusion Criteria:

• Having at least 2 symptomatic episodes of cystitis during the last 6 months including at least 1 episode confirmed as being bacterial cystitis (by an urine bacterial analysis or validated by a doctor (date of appointment, list of prescribed treatments) ;
• Whose symptomatic episodes of cystitis over the past 6 months have had a significant impact on quality of life / urinary comfort (ACSS QoL> 2);
• Having a smartphone compatible with the NURSTRIAL® data collection application;
• Not opposing the collection and processing of their personal data.

Exclusion Criteria:

• Presenting urinary discomfort with a severe impact on quality of life (ACSS QoL> 7) during the last 24 hours prior to inclusion;
• Pregnant, breastfeeding or planning to become pregnant during the study;
• Under antibiotic treatment (or during the last month preceding inclusion);
• Under food supplementation with prebiotics or probiotics or having stopped it less than a month before inclusion;
• Having had recourse to a prophylactic treatment (cranberry juice) 15 days before inclusion;
• Having had local estrogen therapy during the 3 months preceding inclusion;
• Diabetic;
• Presenting an immunosuppressive disease;
• Presenting pelvic floor abnormalities (Cystocele surgery, etc.);
• Presenting or having a history of kidney disease (including kidney stones, urinary tract abnormalities, pyelonephritis, kidney failure, kidney transplantation);
• For women consuming supplementation: known allergy to plants of the cranberry family or to one of the components of the products.

The first 80 women of the CEN Nutriment (Clinical Investigation Center) volunteer panel corresponding to the selection criteria and wishing to participate in the study.