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The role of the coagulation parameters in predicting the severity of COVID-19 disease will be assessed
In COVID-19 patients the coagulation parameters Prothrombin concentration (PC), Activated Partial Thromboplastin Time (aPTT), D Dimer, Antithrombin III (ATIII) and Fibrinogen are measured and correlation with disease severity is to be investigated
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mild cases | Patients with confirmed COVID-19 and with mild disease |
| |
| Severe cases | Patients with confirmed COVID-19 and with severe disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood coagulation profile | Diagnostic Test | Venous blood sample for measurement of blood coagulation profile |
|
| Measure | Description | Time Frame |
|---|---|---|
| correlation of disease severity with results of laboratory test | The results of blood coagulation profile will be correlated with degree of severity of illness | Baseline results of coagulation profile and baseline disease severity assessment |
| Measure | Description | Time Frame |
|---|---|---|
| Agreement of abnormalities in coagulation profile with measured inflammatory markers | The inflammatory markers will be measured and correlation with abnormalities in coagulation profile will be assessed | baseline measurement of inflammatory markers |
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Inclusion Criteria:
● Confirmed cases with COVID 19
Exclusion Criteria:
● Known history of blood coagulopathy disorder
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Cases with confirmed COVID 19 disease
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| Name | Affiliation | Role |
|---|---|---|
| Hend mohamed A Esmaeel, M.D | Sohag Univesity | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag University | Sohag | 82425 | Egypt | |||
| Sohag University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32109011 | Background | Fauci AS, Lane HC, Redfield RR. Covid-19 - Navigating the Uncharted. N Engl J Med. 2020 Mar 26;382(13):1268-1269. doi: 10.1056/NEJMe2002387. Epub 2020 Feb 28. No abstract available. | |
| 32073213 | Background | Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020 Apr;18(4):844-847. doi: 10.1111/jth.14768. Epub 2020 Mar 13. |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| Sohag |
| 82524 |
| Egypt |
| 32282949 | Background | Terpos E, Ntanasis-Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M, Psaltopoulou T, Gerotziafas G, Dimopoulos MA. Hematological findings and complications of COVID-19. Am J Hematol. 2020 Jul;95(7):834-847. doi: 10.1002/ajh.25829. Epub 2020 May 23. |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |