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| Name | Class |
|---|---|
| Laboratoire de Psychologie et NeuroCognition | OTHER |
| University Hospital, Geneva | OTHER |
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Anorexia nervosa is a serious psychiatric illness whose causes remain poorly understood, and which remains difficult to treat to this day. Many clinical manifestations of this disease can have their origin in abnormalities in the perception of signals coming from inside the body, but this remains to be demonstrated. In recent years, research in healthy subjects has shown how the brain constantly perceives the viscera (heart, lungs, stomach). The examiners will use these new, objective and validated methods to explore how the brain processes information from the viscera (interoception) in anorexic patients. In practice, they will quantify the coupling between the cardiac cycle and involuntary eye movements, as well as between the respiratory cycle and voluntary actions such as pressing a button. Finally, by simultaneously recording the electrical activity of the brain, and that of the stomach, the examiners will measure the coupling between the brain and the stomach. All these measurements, which will be compared between a population of patients and healthy subjects, will make it possible to determine whether anorexic patients have an alteration in the perception of their internal body signals and whether this damage affects several organs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control |
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| AN group |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Clinical and experimental session | Other | Psychologic profile with standardized interview and scales (see below for details: SCID, BDI, STAI, BPQ, EDE Q, Pictorial Body Image Scale (PBIS) and EDI). Measure the stomach-brain synchrony during EEG/EGG resting state, the distribution of voluntary actions across the respiratory phase, and the distribution of saccadic eye movements across the cardiac-cycle. |
| Measure | Description | Time Frame |
|---|---|---|
| measure brain-stomach interactions using phase-amplitude coupling between the gastric phase and the amplitude of the cortical alpha rhythm. | Examiners will directly measure brain-stomach interactions using phase-amplitude coupling between the gastric phase and the amplitude of the cortical alpha rhythm. | Experimental session - 10 days maximum after inclusion |
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Inclusion Criteria - AN groups:
Inclusion Criteria - control groups:
Exclusion Criteria for both groups:
In addition, for the control group,
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patients with anorexia nervosa (group AN) and healthy control subjects (group C)
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nathalie Godart, PU-PH | Contact | 0145894339 | nathalie.godart@fsef.net | |
| Marco Solca, Dr | Contact | marco.solca@hcuge.ch |
| Name | Affiliation | Role |
|---|---|---|
| Marco Solca, Dr | ENS | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ENS | Recruiting | Paris | Île-de-France Region | 75005 | France |
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| ID | Term |
|---|---|
| D000855 | Anorexia |
| D000856 | Anorexia Nervosa |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001068 | Feeding and Eating Disorders |
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| D001523 | Mental Disorders |