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low recruitment, end of COVID-19 pandemic
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| Name | Class |
|---|---|
| European University at St. Petersburg | OTHER |
| Medical Institute named after Berezin Sergey | UNKNOWN |
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This is an observational case-control study to evaluate COVID-19 vaccine effectiveness against hospitalisation with COVID-19 related conditions in St. Petersburg, Russia. Two sets of cases and control will be retrospectively analyzed to compare vaccination proportions and other characteristics to infer vaccine effectiveness from odds ratios. The first set of cases will be extracted from the data on hospitalisation of patients with COVID-19 to First Pavlov State Medical University of Saint-Petersburg hospitals, and controls will be patients hospitalised with other conditions. The second set of cases and controls will be based on patients referred to Medical Institute named after Berezin Sergey for computed tomography. Cases will be patients with positive SARS-CoV-2 status computed tomography confirmed pneumonia or patients referred to hospitalisation, and control will be patients without pneumonia and not referred to hospitalisation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients hospitalised to clinics of First Pavlov State Medical University of Saint - Petersburg | 450 cases - patients hospitalised with COVID-19 450 control - patients hospitalised without COVID-19 in the same period (surgical, oncological, cardiological, ophthalmologic, gastroenterological departments) |
| |
| Patients referred to Medical Institute named after Berezin Sergey for computed tomography | Cases - patients with pneumonia confirmed after computed tomography. Controls - patients without pneumonia after computed tomography. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| COVID-19 Vaccines | Biological | "Gam-COVID-Vac" "EpiVacCorona" "COVIVAC" |
|
| Measure | Description | Time Frame |
|---|---|---|
| Effectiveness of full vaccination against hospitalization with COVID-19 pneumonia | Full vaccination effectiveness is calculated based on the odds ratio of vaccination proportions in cases and controls, adjusted for other patient characteristics. Full vaccination status is assigned after two weeks of the second dose for each vaccine separately. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Effectiveness of partial vaccination against hospitalization with COVID-19 pneumonia | Partial vaccination effectiveness is calculated based on the odds ratio of vaccination proportions in cases and controls, adjusted for other patient characteristics. Partial vaccination status is assigned after two weeks of the first dose for each vaccine separately. | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
- Refusal to provide information for research purposes at the time of hospitalization or reference to computed tomography
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Residents of Saint-Petersburg, Russia
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mikhail Cherkashin | Saint Petersburg | Sankt-Peterburg | 197022 | Russia | ||
| Oksana Stanevich |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36217139 | Derived | Barchuk A, Bulina A, Cherkashin M, Berezina N, Rakova T, Kuplevatskaya D, Skougarevskiy D, Okhotin A. Gam-COVID-Vac, EpiVacCorona, and CoviVac effectiveness against lung injury during Delta and Omicron variant surges in St. Petersburg, Russia: a test-negative case-control study. Respir Res. 2022 Oct 10;23(1):276. doi: 10.1186/s12931-022-02206-3. |
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| ID | Term |
|---|---|
| D000086663 | COVID-19 Vaccines |
| ID | Term |
|---|---|
| D014765 | Viral Vaccines |
| D014612 | Vaccines |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
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| Effectiveness of vaccination against hospitalization with COVID-19 pneumonia in different age groups | Evaluate vaccine effectiveness in different age groups (<20, 20-29, 30-39, 40-49, 50-59, 60-69, >70) | 3 months |
| Saint Petersburg |
| 197022 |
| Russia |