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| Name | Class |
|---|---|
| Institute of Naval Medicine (UK) | UNKNOWN |
| CTCRM Lympstone (UK) | UNKNOWN |
| University of Portsmouth | OTHER |
| Public Health Wales |
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The arduous nature of military training and operations require personnel to encounter high heat load, e.g., during intense physical exertion, particularly in the heat. These conditions reduce operational effectiveness and expose personnel to a risk of incapacitation and death from exertional heat illness (EHI).
The aim of this study is to examine traditional and novel risk factors that may increase thermal strain and EHI likelihood in military recruits undergoing strenuous physical exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exertional heat illness | Participants who experience an atypical elevation in thermal strain or an EHI undergoing strenuous physical exercise. |
| |
| Control | Participants who do not experience an atypical elevation in thermal strain or an EHI undergoing strenuous physical exercise. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Core temperature monitoring | Other | Core temperature will be monitored on the day of exercise |
|
| Measure | Description | Time Frame |
|---|---|---|
| Body mass index in EHI and control group | Baseline | |
| Fitness in EHI and control group - participants ranked by time to complete fitness test | Baseline | |
| Core temperature in EHI and control group | 1 Day | |
| Heart rate in EHI and control group | 2 Hours | |
| Urine osmolality in EHI and control group | Baseline | |
| Sleep quality and quantity, measured by Pittsburgh Sleep Quality Index, in EHI and control group | 0-21 Scale. Higher score indicates worse outcome | Throughout study - up to 1 week |
| Sleep quality, measured by actigraphy, between EHI and control group | Throughout study - up to 1 week | |
| Sleep quantity, measured by actigraphy, between EHI and control group | Throughout study - up to 1 week | |
| Circulating Interleukin 6 in EHI and control group | Baseline | |
| Circulating C-Reactive Protein in EHI and control group | Baseline | |
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Inclusion Criteria:
Exclusion Criteria:
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Participants who experience and participants who do not experience an atypical elevation in thermal strain or an EHI undergoing strenuous physical exercise.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Commando Training Centre Royal Marine | Lympstone | Devon | EX8 5AR | United Kingdom |
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| ID | Term |
|---|---|
| D018882 | Heat Stress Disorders |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| D059349 | Urine Specimen Collection |
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
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| OTHER_GOV |
| Bangor University (UK) | UNKNOWN |
| Headquarters Army Recruiting and Initial Training Command (UK) | UNKNOWN |
| Defence Science and Technology (UK) | UNKNOWN |
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Saliva sample, stool sample
| Questionnaires | Behavioral | Questionnaires will be completed at baseline and on the day of exercise |
|
| Heart rate monitoring | Other | Heart rate will be monitored on the day of exercise |
|
| Urine collection | Other | Urine samples will be collected at baseline and on the day of exercise |
|
| Sleep monitoring | Other | Sleep will be monitored at baseline and on the day of exercise |
|
| Blood collection | Other | Blood samples will be completed at baseline |
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| Saliva collection | Other | Saliva samples will be collected at baseline and on the day of exercise |
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| Throat swab collection | Other | Throat swab samples will be collected at baseline and on the day of exercise |
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| Stool collection | Other | Stool samples will be collected at baseline and on the day of exercise |
|
| Circulating Creatine kinase in EHI and control group |
| Baseline |
| Circulating Aspartate Aminotransferase in EHI and control group | Baseline |
| Circulating Alanine Aminotransferase in EHI and control group | Baseline |
| Circulating Claudin 3 in EHI and control group | Baseline |
| Circulating Zonulin in EHI and control group | Baseline |
| Circulating Lipopolysaccharide binding protein in EHI and control group | Baseline |
| Circulating immunoglobulin E in EHI and control group | Baseline |
| Salivary cortisol in EHI and control group | Throughout study - up to 1 week |
| Detection of infectious pathogens in EHI and control groups | Throughout study - up to 1 week |
| Respiratory illness symptomology, measured by Jackson common cold questionnaire, in EHI and control group | 0-24 Scale. Higher score indicates worse outcome | Throughout study - up to 1 week |
| Gastrointestinal illness symptomology, measured by gastrointestinal symptoms questionnaire, in EHI and control group | 0-10 Scale per symptom. Higher score indicates worse outcome | Throughout study - up to 1 week |
| Abundance and diversity of gastrointestinal microbiota in EHI and control group | Baseline |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |