Diabetes is a major cause of morbidity and mortality worldwide and it contributes substantially to healthcare costs. Type 2 Diabetes mellitus is the most common type of diabetes accounting for approximately (90%) of all cases.

Type 2 DM carries a two to six times risk of death from cardiovascular etiologies, such that age adjusted prevalence of white Americans for coronary artery disease (CAD) is double in those with type 2 DM than those without .

Inclusion Criteria:

100 Cases were selected with type II (DM) patients who had been admitted for coronary angiography because of suspected (CAD) to the Catheter lab unit of Sohag University Hospital.

Exclusion Criteria:

1. Type 1 DM.
2. Smoker.
3. Hypertension.
4. Pregnant women.
5. Patient known non diabetic retinal disease non diabetic. nephropathy or neuropathy.
6. History of familial dyslipidemia.

This study enrolled 100 patients known type 2 DM with coronary artery disease and coronary angiography done to diagnosis coronary artery disease then assess microvascular complications in those patients by fundus examination-neurologic examination-albumin creatinine ratio-EGFR. IN STUDY investigator exclude any other cause can lead to microvascular complications example hypertension.

aim of study to early predict coronary artery disease in patient with type 2 DM if microvascular complication presenet by non invasive investigation as stress ECG.